OPEN Foundation

Author name: OPEN Foundation

Sex differences and serotonergic mechanisms in the behavioural effects of psilocin

Abstract

Psilocybin has recently attracted a great deal of attention as a clinical research and therapeutic tool. The aim of this paper is to bridge two major knowledge gaps regarding its behavioural pharmacology – sex differences and the underlying receptor mechanisms. We used psilocin (0.25, 1 and 4 mg/kg), an active metabolite of psilocybin, in two behavioural paradigms – the open-field test and prepulse inhibition (PPI) of the acoustic startle reaction. Sex differences were evaluated with respect to the phase of the female cycle. The contribution of serotonin receptors in the behavioural action was tested in male rats with selective serotonin receptor antagonists: 5-HT1A receptor antagonist (WAY100635 1 mg/kg), 5-HT2A receptor antagonist (MDL100907 0.5 mg/kg), 5-HT2B receptor antagonist (SB215505 1 mg/kg) and 5-HT2C receptor antagonist (SB242084 1 mg/kg). Psilocin induced dose-dependent inhibition of locomotion and suppression of normal behaviour in rats (behavioural serotonin syndrome, impaired PPI). The effects were more pronounced in male rats than in females. The inhibition of locomotion was normalized by 5-HT1A and 5-HT2B/C antagonists; however, PPI was not affected significantly by these antagonists. Our findings highlight an important issue of sex-specific reactions to psilocin and that apart from 5-HT2A-mediated effects 5-HT1A and 5-HT2C/B receptors also play an important role. These findings have implications for recent clinical trials.

Tylš, F., Páleníček, T., Kadeřábek, L., Lipski, M., Kubešová, A., & Horáček, J. (2015). Sex differences and serotonergic mechanisms in the behavioural effects of psilocin. Behavioural pharmacology. https://dx.doi.org/10.1097/FBP.0000000000000198

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Return of the lysergamides. Part I: Analytical and behavioural characterization of 1-propionyl-d-lysergic acid diethylamide (1P-LSD)

Abstract

1-Propionyl-d-lysergic acid diethylamide hemitartrate (1P-LSD) has become available as a ‘research chemical’ in the form of blotters and powdered material. This non-controlled derivative of d-lysergic acid diethylamide (LSD) has previously not been described in the published literature despite being closely related to 1-acetyl-LSD (ALD-52), which was developed in the 1950s. This study describes the characterization of 1P-LSD in comparison with LSD using various chromatographic and mass spectrometric methods, infrared and nuclear magnetic resonance spectroscopy. An important feature common to LSD and other serotonergic hallucinogens is that they produce 5-HT2A-receptor activation and induce the head-twitch response (HTR) in rats and mice. In order to assess whether 1P-LSD displays LSD-like properties and activates the 5-HT2A receptor, male C57BL/6 J mice were injected with vehicle (saline) or 1P-LSD (0.025–0.8 mg/kg, IP) and HTR assessed for 30 min using magnetometer coil recordings. It was found that 1P-LSD produced a dose-dependent increase in HTR counts, and that it had ~38% (ED50 = 349.6 nmol/kg) of the potency of LSD (ED50 = 132.8 nmol/kg). Furthermore, HTR was abolished when 1P-LSD administration followed pretreatment with the selective 5-HT2A receptor antagonist M100907 (0.1 mg/kg, SC), which was consistent with the concept that the behavioural response was mediated by activation of the 5-HT2A receptor. These results indicate that 1P-LSD produces LSD-like effects in mice, consistent with its classification as a serotonergic hallucinogen. Nevertheless, the extent to which 1P-LSD might show psychoactive effects in humans similar to LSD remains to be investigated.

Brandt, S. D., Kavanagh, P. V., Westphal, F., Stratford, A., Elliott, S. P., Hoang, K., … & Halberstadt, A. L. (2015). Return of the lysergamides. Part I: Analytical and behavioural characterization of 1‐propionyl‐d‐lysergic acid diethylamide (1P‐LSD). Drug Testing and Analysis. http://dx.doi.org/10.1002/dta.1884
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Breaking Convention 2015: Een terug-(en vooruit-)blik

BC_report_2Psychedelische onderzoekers uit de hele wereld kwamen samen om hun bevindingen te presenteren op de derde tweejaarlijkse conferentie Breaking Convention (BC). De conferentie vond plaats van 10 tot 12 juli op het Greenwich College in Londen en gaf een podium aan 140 sprekers uit zo’n 40 landen, alsmede aan performers, artiesten en muzikanten. Er kwamen meer dan 800 mensen op het evenement af, waar gerenommeerde sprekers zoals de professors David E. Nichols, David J. Nutt en Roland Griffiths aanwezig waren, samen met een grote verscheidenheid aan academici uit verschillende vakgebieden.

Volgens Dr. Ben Sessa, een van de organisatoren, was de conferentie een succes: “We hebben veel geweldige feedback gehad. BC is echt een ‘home grown’ aangelegenheid, omdat bijna een derde van de bezoekers op een of andere manier participeert. Mensen voelen in grote mate dat ze echt onderdeel zijn van de conferentie, wat betekent dat de sfeer geweldig is en er veel belangrijke connecties worden gelegd.” Sessa was een van de medeoprichters van BC in 2011, en legt uit hoe de conferentie sindsdien momentum heeft opgebouwd: “We hebben BC ingericht als een platform om psychedelisch onderzoek en de psychedelische cultuur te presenteren. De conferentie is enorm gegroeid en we hopen dat ze zich blijft uitbreiden en jonge mensen en ervaren enthousiastelingen blijft inspireren om dit belangrijke onderwerp uit te dragen.”

Een van de deelnemers was Michael Kugel, een student geneeskunde uit Sydney, Australië. Hij legde 17.000 kilometer af om ’s werelds leidende onderzoekers naar medicinale cannabis en psychedelisch onderzoek te ontmoeten. Hij vond de reis de moeite waard, en bewijst dat Sessa’s hoop niet vergeefs is. “Ik heb hier veel geweldige mensen ontmoet”, zegt Kugel. “Ik heb gepraat met Allan Badiner, de auteur van Zig Zag Zen, en hij stelde me voor aan de oprichter van MAPS, Rick Doblin, die me weer vertelde over een psychiater die in Australië toestemming probeert te krijgen om onderzoek te doen naar MDMA voor oorlogsveteranen die lijden aan PTSS. Tijdens de lunch kwam ik Lumír Hanuš tegen, die lid was van het team dat anandamide [fusion_builder_container hundred_percent=”yes” overflow=”visible”][fusion_builder_row][fusion_builder_column type=”1_1″ background_position=”left top” background_color=”” border_size=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none”][een endogene cannabinoïde, red.] ontdekte, en momenteel werkt met Raphael Mechoulam. Ik bood hem mijn (beperkte) laboratoriumvaardigheden aan – we zien wel waar dat toe leidt. Tot nu toe voelt het allemaal erg goed.”

Tehseen Noorani, een onderzoeker die samen met Roland Griffiths en Matthew Johnson heeft meegewerkt aan een  psilocybinestudie aan Johns Hopkins, heeft geen moment getwijfeld om naar BC te komen: “Ik doe onderzoek naar psychedelica en deze conferenties zijn zeldzaam. Ze zijn ook groot, dus het is logisch om te komen om mijn werk te presenteren en te volgen wat er nog meer gaande is. Als je hier bent, kom je er achter dat dat heel veel is – er zijn zoveel kleine groepjes die actief zijn overal ter wereld.”

Noorani vindt het belangrijk om te proberen geldschieters te overtuigen dat psychedelica een onderwerp is dat het onderzoeken waard is . “Voor mij zijn er veel wetenschappelijke vakgebieden,” zei hij. “Ik werk met farmacologen en het lijkt vrij duidelijk waar de klinische onderzoeken naartoe moeten. Er is al een toenemende acceptatie van de indrukwekkende resultaten van strikt wetenschappelijk onderzoek, dus wat we nu nog echt nodig hebben is geld.” Hij benadrukt ook het belang van het serieus nemen van sociaalwetenschappelijk onderzoek rond psychedelica: “Ik heb een achtergrond in de antropologie, en ik zou zeggen dat antropologisch werk serieuzer moet worden genomen. Ten eerst moet onderzoek de belangrijke hedendaagse antropologische en politieke vragen met elkaar verbinden. Ten tweede moet etnografisch onderzoek worden erkend als serieus onderzoek door de zogenaamde ‘hardere’ wetenschappen, maar ook door de maatschappij, omdat interesse in psychedelica interesse is in erg diepgaande dingen.”

Ook Levente Móró, een bewustzijnswetenschapper uit Finland die momenteel in Hongarije woont, vond op BC waar hij naar op zoek was: “Samen met de tweejaarlijkse conferentie van Stichting OPEN is BC de belangrijkste Europese samenkomst van het internationale psychedelische wetenschappelijke veld. Ik wilde worden bijgepraat over de status van het huidige onderzoek, nieuwe en oude medeonderzoekers ontmoeten, en vertellen over mijn eigen ideeën om feedback te krijgen. De conferentie bood grote hoeveelheden kennis, vanuit al de verschillende vakgebieden die gerelateerd zijn aan psychedelica. Het is goed om verse input en inzichten te ontvangen, ook van buiten mijn eigen onderzoeksgebieden. Ook was het erg leuk om meer mensen uit Finland te ontmoeten, als resultaat van het onlangs georganiseerde psychedelische wetenschapsactivisme.” Een groep Finse academici die proberen om praktisch onderzoek en evidence-based informatie over psychedelica te promoten, organiseerde in april hun eerste kleine psychedelische seminar, met presentaties van onder andere Teri Krebs, Murtaza Majeed en Helle Kaasik.

Móró’s eigen presentatie op BC was gebaseerd op een bioethische analyse van de Single Convention on Narcotic Drugs uit 1961, die hij had gemaakt samen met zijn collega Imre Bárd, die afwezig was. Hij focuste op representaties van ‘het kwade’ en toonde hoe de drugswetten van de VN een taalgebruik van religieuze immoraliteit hanteerden om drugsverboden te rechtvaardigen. Ondanks het feit dat zijn presentatie gebaseerd was op een conventie van een halve eeuw geleden, vertoonde ze raakpunten met de huidige wetgeving. Een van de hot topics die werden genoemd tijdens veel van de BC presentaties was de nieuwe Psychoactive Substances Bill (2015), die slechts een aantal weken voor de conferentie door de Britse overheid werd voorgesteld. Deze nieuwe wet zou de regulering van de meeste psychoactieve stoffen (behalve alcohol en tabak) verstrengen en daarmee psychedelisch onderzoek nog moeilijker maken. Op de conferentiewebsite werd een open brief gepubliceerd, gericht aan de Britse premier, waarin de ondergetekenden aandringen op een heroverweging van de inhoud van het wetsvoorstel. De brief werd getekend door meer dan 40 professionals, waaronder academici, vroegere en huidige parlementsleden en politieambtenaren.

Deze meer politiek actieve rol van psychedelische onderzoekers werd verwelkomd door Levente Móró: “Het was mooi om te zien dat psychedelische wetenschappers zich steeds meer bezighouden met kwesties rondom de hervorming van het drugsbeleid.” Ondanks de mogelijke aanscherping van de regulering in het Verenigd Koninkrijk, leek Ben Sessa optimistisch over de toekomst van psychedelisch onderzoek. “Psychedelisch onderzoek vereist enorme PR-inspanningen. De meeste onderzoekers geloven dat psychedelische drugs nuttige, veilige en doeltreffende hulpmiddelen zijn voor genezing, groei en ontwikkeling. Maar helaas kleeft er voor het grootste deel van de publieke opinie nog veel stigma en desinformatie aan deze fascinerende stoffen. Dit betekent dat we ons tot op zekere hoogte moeten loskoppelen van de ’hippies’ en moeten laten zien dat ‘normale’ alledaagse mensen psychedelica op een veilige manier kunnen gebruiken met persoonlijke en maatschappelijke baten. Een manier om dit te doen is om psychedelische medicijnen meer media-aandacht te geven. Dit is gedeeltelijk waarom ik mijn roman ‘To Fathom Hell Or Soar Angelic’ geschreven heb, die op BC15 werd gepresenteerd. Ondertussen ga ik, samen met mijn collega-onderzoekers, door met het uitvoeren van degelijk wetenschappelijk onderzoek om de veiligheid en effectiviteit van psychedelische therapie aan te tonen.”

Een van de manieren om het stigma te verminderen zou kunnen zijn dat onderzoekers openlijk praten over hun eigen ervaringen. Maar zou dit hun geloofwaardigheid als wetenschappers kunnen schaden? Noorani: “Als onderzoeker zou ik zeggen dat er echt een dilemma bestaat rond het al dan niet toegeven dat je (geen) psychedelica hebt genomen, met betrekking tot de positieve of negatieve weerslag dat dit kan hebben op de legitimiteit van je onderzoek.” Móró gelooft dat wetenschappelijke geloofwaardigheid niet zou moeten liggen aan de persoon achter de onderzoeker: “Het zou kunnen dat onderzoekers inzichten verkrijgen uit hun eigen ervaringen, of meer gemotiveerd raken door fenomenen te onderzoeken die ze persoonlijk fascinerend en betekenisvol vinden. Daarnaast zou wetenschappelijke geloofwaardigheid niet afhankelijk moeten zijn van de persoonlijke achtergrond van de onderzoeker. Ze zou objectief verifieerbaar en onafhankelijk van de niet-wetenschappelijke eigenschappen van de onderzoeker moeten zijn.”

Hoewel Sessa openlijk zijn eigen ervaringen bespreekt, erkent hij ook hoe juridische beperkingen invloed kunnen hebben op de manier waarop professionals publiekelijk spreken over hun psychedelicagebruik: “Ik heb het geluk gehad dat ik in de afgelopen 6 jaar kon deelnemen aan een aantal legale psychedelische onderzoeken, zodat ik officieel kan zeggen dat ik ketamine, LSD en psilocybine heb genomen tijdens die onderzoeken.” Sessa steunt het idee dat het ‘toegeven’ van veilige en heilzame ervaringen een goede manier kan zijn ter bevordering van de emancipatie van deze stoffen: “Deze methode heeft goed gewerkt voor het normaliseren van homoseksualiteit in de afgelopen decennia. Maar ik begrijp ook de professionals – met name dokters – die hier onwillig tegenover staan. Het bezit van illegale drugs wordt in de meeste landen nog steeds bestraft.”

Volgend jaar zal de speciale sessie van de UN General Assembly Special Session on Drugs (UNGASS) onder andere richting geven voor de toekomst van psychedelisch onderzoek, en de resultaten zullen waarschijnlijk uitvoerig gepresenteerd, bediscussieerd en gedebatteerd worden tijdens de volgende BC in 2017.

Dit verslag is gebaseerd op ter plekke opgenomen interviews en email interviews achteraf.

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Validation of the revised Mystical Experience Questionnaire in experimental sessions with psilocybin

Abstract

The 30-item revised Mystical Experience Questionnaire (MEQ30) was previously developed within an online survey of mystical-type experiences occasioned by psilocybin-containing mushrooms. The rated experiences occurred on average eight years before completion of the questionnaire. The current paper validates the MEQ30 using data from experimental studies with controlled doses of psilocybin. Data were pooled and analyzed from five laboratory experiments in which participants (n=184) received a moderate to high oral dose of psilocybin (at least 20 mg/70 kg). Results of confirmatory factor analysis demonstrate the reliability and internal validity of the MEQ30. Structural equation models demonstrate the external and convergent validity of the MEQ30 by showing that latent variable scores on the MEQ30 positively predict persisting change in attitudes, behavior, and well-being attributed to experiences with psilocybin while controlling for the contribution of the participant-rated intensity of drug effects. These findings support the use of the MEQ30 as an efficient measure of individual mystical experiences. A method to score a “complete mystical experience” that was used in previous versions of the mystical experience questionnaire is validated in the MEQ30, and a stand-alone version of the MEQ30 is provided for use in future research.

Barrett, F. S., Johnson, M. W., & Griffiths, R. R. (2015). Validation of the revised Mystical Experience Questionnaire in experimental sessions with psilocybin. Journal of psychopharmacology (Oxford, England). http://dx.doi.org/10.1177/0269881115609019
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Banisteriopsis caapi, a Forgotten Potential Therapy for Parkinson’s Disease?

Abstract

Banisteriopsis caapi, a liana indigenous to the Amazon basin with metagnomigenic properties and possible anti-depressant effects is one of the natural sources of harmala alkaloids. A summary of early trials with extracts of Banisteriopsis caapi and Peganum harmala (from which harmine was first isolated) in the 1920s and 1930s on various forms of parkinsonism is given as well as a brief overview of the known pharmacological properties of harmine. Despite its earlier abandonment because of perceived weaker efficacy than solanaceous alkaloids like scopolamine and hyoscine we propose that harmine should be reconsidered as a potential rapidly acting anti-Parkinsonian agent.

Djamshidian, A., Bernschneider‐Reif, S., Poewe, W., & Lees, A. J. (2015). Banisteriopsis caapi, a Forgotten Potential Therapy for Parkinson’s Disease?. Movement Disorders Clinical Practice. http://dx.doi.org/10.1002/mdc3.12242
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Banisteriopsis caapi, a Forgotten Potential Therapy for Parkinson's Disease?

Abstract

Banisteriopsis caapi, a liana indigenous to the Amazon basin with metagnomigenic properties and possible anti-depressant effects is one of the natural sources of harmala alkaloids. A summary of early trials with extracts of Banisteriopsis caapi and Peganum harmala (from which harmine was first isolated) in the 1920s and 1930s on various forms of parkinsonism is given as well as a brief overview of the known pharmacological properties of harmine. Despite its earlier abandonment because of perceived weaker efficacy than solanaceous alkaloids like scopolamine and hyoscine we propose that harmine should be reconsidered as a potential rapidly acting anti-Parkinsonian agent.

Djamshidian, A., Bernschneider‐Reif, S., Poewe, W., & Lees, A. J. (2015). Banisteriopsis caapi, a Forgotten Potential Therapy for Parkinson’s Disease?. Movement Disorders Clinical Practice. http://dx.doi.org/10.1002/mdc3.12242
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Kappa Opioids, Salvinorin A and Major Depressive Disorder

Abstract

Opioids are traditionally associated with pain, analgesia and drug abuse. It is now clear, however, that the opioids are central players in mood. The implications for mood disorders, particularly clinical depression, suggest a paradigm shift from the monoamine neurotransmitters to the opioids either alone or in interaction with monoamine neurons. We have a special interest in dynorphin, the last of the major endogenous opioids to be isolated and identified. Dynorphin is derived from the Greek word for power, dynamis, which hints at the expectation that the neuropeptide held for its discoverers. Yet, dynorphin and its opioid receptor subtype, kappa, has always taken a backseat to the endogenous b – endorphin and the exogenous morphine that both bind the mu opioid receptor subtype. That may be changing as the dynorphin/ kappa system has been shown to have different, often opposite, neurophysiological and behavioral influences. This includes major depressive disorder (MDD). Here, we have undertaken a review of dynorphin/ kappa neurobiology as related to behaviors, especially MDD. Highlights include the unique features of dynorphin and kappa receptors and the special relation of a plant- based agonist of the kappa receptor salvinorin A. In addition to acting as a kappa opioid agonist, we conclude that salvinorin A has a complex pharmacologic profile , with potential additional mechanisms of action. Its unique neurophysiological effects make Salvinorina A an ideal candidate for MDD treatment research.

T Taylor and Francesca Manzella, G. Kappa Opioids, Salvinorin A and Major Depressive Disorder. Current Neuropharmacology, 13. http://dx.doi.org/10.2174/1570159X13666150727220944
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Current Status of Ketamine and Related Therapies for Mood and Anxiety Disorders

Abstract

Major depressive disorder (MDD) is a leading cause of disability worldwide. Despite a plethora of established treatments, less than one third of individuals with MDD achieve stable remission of symptoms. Given limited efficacy and significant lag time to onset of therapeutic action among conventional antidepressants, interest has shifted to treatments that act outside of the monoamine neurotransmitter systems (e.g., serotonin, norepinephrine, and dopamine). Preclinical and clinical research on the glutamate system has been particularly promising in this regard. Accumulating evidence shows support for a rapid antidepressant effect of ketamine—a glutamate N-methyl-d-aspartate (NMDA) receptor antagonist. The present article reviews the pharmacology, safety, and efficacy of ketamine as a novel therapeutic agent for mood and anxiety disorders. The majority of clinical trials using ketamine have been conducted in patients with treatment-resistant forms of MDD; recent work has begun to examine ketamine in bipolar disorder, post-traumatic stress disorder, and obsessive–compulsive disorder. The impact of ketamine on suicidal ideation is also discussed. The current status and prospects for the identification of human biomarkers of ketamine treatment response and hurdles to treatment development are considered. We conclude by considering modulators of the glutamate system other than ketamine currently in development as potential novel treatment strategies for mood and anxiety disorders.

Costi, S., Van Dam, N. T., & Murrough, J. W. (2015). Current Status of Ketamine and Related Therapies for Mood and Anxiety Disorders. Current Behavioral Neuroscience Reports, 1-10. https://dx.doi.org/10.1007/s40473-015-0052-3
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Acute Biphasic Effects of Ayahuasca

Abstract

Ritual use of ayahuasca, an amazonian Amerindian medicine turned sacrament in syncretic religions in Brazil, is rapidly growing around the world. Because of this internationalization, a comprehensive understanding of the pharmacological mechanisms of action of the brew and the neural correlates of the modified states of consciousness it induces is important. Employing a combination of electroencephalogram (EEG) recordings and quantification of ayahuasca’s compounds and their metabolites in the systemic circulation we found ayahuasca to induce a biphasic effect in the brain. This effect was composed of reduced power in the alpha band (8–13 Hz) after 50 minutes from ingestion of the brew and increased slow- and fast-gamma power (30–50 and 50–100 Hz, respectively) between 75 and 125 minutes. Alpha power reductions were mostly located at left parieto-occipital cortex, slow-gamma power increase was observed at left centro-parieto-occipital, left fronto-temporal and right frontal cortices while fast-gamma increases were significant at left centro-parieto-occipital, left fronto-temporal, right frontal and right parieto-occipital cortices. These effects were significantly associated with circulating levels of ayahuasca’s chemical compounds, mostly N,N-dimethyltryptamine (DMT), harmine, harmaline and tetrahydroharmine and some of their metabolites. An interpretation based on a cognitive and emotional framework relevant to the ritual use of ayahuasca, as well as it’s potential therapeutic effects is offered.

Schenberg E.E., Alexandre J.F.M., Filev R., Cravo A.M., Sato J.R., Muthukumaraswamy S.D., et al. (2015) Acute Biphasic Effects of Ayahuasca. PLoS ONE 10(9): e0137202. http://dx.doi.org/10.1371/journal.pone.0137202
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Breaking Convention 2015: Looking back (and forward)

BC_report_2Psychedelic researchers gathered from all over the world to present their findings at the third biannual Breaking Convention conference (BC). The conference took place at Greenwich College in London between 10 and 12 July and hosted 140 presenters from about 40 countries as well as performers, artists and musicians. Over 800 people attended the event, which included renowned presenters such as professors David E. Nichols, David J. Nutt and Roland Griffiths, along with a great variety of academics from different disciplines.

According to Dr. Ben Sessa, one of the conference’s organisers, the conference was a success: “We have had a lot of great feedback. BC is a very ‘home grown’ affair, with almost a third of delegates participating in one way or another. People feel a great deal of personal ownership over the conference, which means the atmosphere is great and a lot of important networking gets done.” Sessa was one of the co-founders of BC in 2011, and explains how the conference has built momentum since then: “We set up BC as a platform to showcase psychedelic research and culture. The conference has grown tremendously and we hope it will continue to expand and inspire young people and seasoned enthusiasts to propagate this important subject.”

One of the participants was Michael Kugel, an undergraduate medical science student from Sydney, Australia. He travelled 17.000 kilometres to meet world leading researchers in current medical cannabis and psychedelic research. He thinks his trip was worthwhile and shows that Sessa´s hopes are not in vain. “I’ve met a lot of great people here”, says Kugel. “I met Allan Badiner, author of Zig Zag Zen, who introduced me to MAPS founder Rick Doblin, who in turn told me about a psychiatrist who is trying to get approval in Australia to study MDMA for PTSD in war veterans. At lunch I bumped into Lumír Hanuš, who was part of the team that discovered anandamide [fusion_builder_container hundred_percent=”yes” overflow=”visible”][fusion_builder_row][fusion_builder_column type=”1_1″ background_position=”left top” background_color=”” border_size=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none”][an endogenous cannabinoid, ed.], and who currently works with Raphael Mechoulam. I offered him my (limited) lab skills – we’ll see where that leads. I´m feeling really good about it all so far.”

For Tehseen Noorani, a researcher who has participated in a psilocybin studie at Johns Hopkins along with Roland Griffiths and Matthew Johnson, coming to BC was a no-brainer: “I do research on psychedelics and these conferences are rare. They are also big, so it totally makes sense to come and present work and find out what else is going on. When you´re in this space, you realise how much is going on – there are so many small pockets of activity all over the world.

Noorani thinks it’s important to undertake efforts to further convince funders that psychedelics are a topic worthy of research. “For me there are a lot of sciences,” he said. “I work with pharmacologists and the steps forward for clinical trials seem to be pretty straightforward. As there´s a growing acceptance of the impressive outcomes of strictly scientific research, what we really need now is money.” He also underlined the importance of taking social scientific research around psychedelics more seriously: “My background is in anthropology, and I would say anthropological work needs to be taken more seriously. Firstly, research needs to connect the important anthropological and political questions of today. Secondly, ethnographic research needs to be recognised as serious research by so-called harder sciences, and by the public, because to be interested in psychedelics is to be interested in pretty profound stuff.”

Levente Móró, a consciousness researcher from Finland currently based in Hungary, also found what he came looking for: “Along with the interlaced biennial conference by the OPEN Foundation, BC is the most important European meeting of the international psychedelic science field. I wanted to get updated about the status of current research, to meet old and new fellow researchers, and to put forward my own ideas and receive feedback. The conference provided abundant amounts of knowledge, from all the various fields related to psychedelics. It is nice to receive fresh input and viewpoints, also from outside my own fields of study. Moreover, it has been extremely nice to meet more people from Finland, as a result of the recently organised psychedelic science activism.” A group of academics in Finland, who aim to promote practical research and evidence-based information on psychedelics, organized their first small psychedelic seminar last April, with presentations from Teri Krebs, Murtaza Majeed and Helle Kaasik, among others.

Móró’s own presentation at BC was based on a bioethical analysis of the 1961 Single Convention on Narcotic Drugs he produced with his colleague Imre Bárd, who wasn’t present. He focused on representations of ‘evil’ and demonstrated how the UN drug laws used a language of religious immorality to justify drug prohibition. His presentation, although based on a convention that was signed over half a century ago, found resonance in current legislative practices. One of the hot topics mentioned during many of the BC presentations was the new Psychoactive Substances Bill (2015), proposed by the British government just weeks before the conference. The new bill would increase the regulation of most psychoactive substances (not including alcohol and tobacco) and further complicate psychedelic research. An open letter was published on the conference website, addressed to the British Prime Minister, in which the undersigned urge for the content of the Bill to be reconsidered. It was signed by over 40 professionals, including academics, former and current members of Parliament and police officials.

This more politically active role of psychedelic researchers was welcomed by Levente Móró: “It was nice to see that psychedelic researchers have been getting involved more and more with drug policy reform issues.” Despite the possible tightening of regulatory practices in the UK, Ben Sessa seemed optimistic about the future of psychedelic research. “Psychedelic research requires a major Public Relations drive. Most researchers believe that psychedelic drugs are useful, safe and efficacious tools for medicine, growth and development. But sadly, for the majority of the general public, high levels of stigma and misinformation remain attached to these fascinating substances. This means we need to detach ourselves, to some extent, from the “hippie” genre and demonstrate that ‘normal’, everyday people can use psychedelics safely and with personal and communal benefits. One way of doing this is to increase the exposure of psychedelic medicine to people everywhere through the media. This is partly why I wrote my novel ‘To Fathom Hell Or Soar Angelic’, which was launched at BC15. In the meantime, my clinical colleagues and I continue to carry out robust scientific studies to determine the safety and efficacy of psychedelic therapy.”

One way to relieve the stigma could be for researchers to openly discuss their own experiences. But could this harm their credibility as scientists? Noorani: “As a researcher I would say there´s a real dilemma around admitting to having (not) taken psychedelics in terms of how it legitimises or delegitimises the research you do.” Móró believes that scientific credibility should not rest on the researcher´s person: “Researchers might get insights from their own experiences, or become more motivated to investigate phenomena they find personally fascinating and meaningful. Besides, scientific credibility should not depend on a researcher’s personal background. It should be objectively assessable and independent of the researcher’s non-scientific traits or parameters.”

While Sessa openly discussed his own experiences, he also recognises how legal restrictions might affect the extent to which professionals publicly speak about their use of psychedelics: “I am fortunate to have participated in a number of legal psychedelic research studies in the last 6 years, so I can say, on the record, that I have taken ketamine, LSD and psilocybin in those studies.” Sessa supports the idea that ‘coming out’ about safe and beneficial experiences could be a good way to forward the emancipation of these substances: “This method worked well for driving the normalisation of homosexuality in recent decades. However, I also understand professionals – especially doctors – who feel reluctant to do this. The possession of illegal drugs is still penalised in most countries.”

Next year, the special session of the UN General Assembly Special Session on Drugs (UNGASS) will, among other things, give directions for the future of psychedelic research, and the outcomes will probably be extensively presented, discussed and debated at the next BC in 2017.

This report is based on on-site recorded interviews and post-conference email interviews.

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