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The Psychedelic Journey of Marlene de Rios

September 9, 2009 / Books, Publications / By

riosA look inside almost half a century of pioneering research in the Amazon and Peru by a noted anthropologist studying hallucinogens, including ayahuasca – Reveals how ayahuasca successfully treats psychological and emotional disorders – Examines adolescent drug use from a cross-cultural perspective – Discusses the deleterious effects of drug tourism in the Amazon Ayahuasca is an alkaloid-rich psychoactive concoction indigenous to South America that has been employed by shamans for millennia as a spirit drug for divinatory and healing purposes. Although the late Harvard ethnobotanist Richard Evans Schultes was credited in the early 1950s as being the first to document the use of ayahuasca, other researchers, such as the distinguished anthropologist Marlene Dobkin de Rios, were responsible for furthering his findings and uncovering the curative capabilities of this amazing compound. “The Psychedelic Journey of Marlene Dobkin de Rios” presents the accumulated experience of de Rios’s 45 years of pioneering field studies in the area of hallucinogens in Peru and the Amazon. Her investigation into ayahuasca–which she undertook in collaboration with more than a dozen traditional Mestizo folk curanderos, shamans, and fellow ethnobotanists–focuses on the use of this revolutionary plant in the treatment of recalcitrant psychological and emotional disorders. She also shares some of her theories that prove that the ancient Maya used psychedelic plants as part of their religious rituals, thereby demonstrating the impact of plant psychedelics on human prehistory. In addition, Dobkin de Rios examines altered states of consciousness derived from the use of biofeedback and hypnosis and discusses her current work on the deleterious effects of drug tourism in the Amazon.

The Psychedelic Journey of Marlene Dobkin de Rios: 45 Years with Shamans, Ayahuasqueros, and Ethnobotanists, by Marlene Dobkin de Rios, Park Street Press, 216 pages.

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Santo Daime: betekenis en aantrekkingskracht van een ayahuasca-religie

December 6, 2021 / Ayahuasca, Dutch, Publicaties, Religious studies, Uncategorized / By

WuytsEr is een nieuw boek verschenen over de Santo Daime van de hand van Jazmin Wuyts, afgestudeerd in culturele antropologie en ontwikkelingssociologie. Het boek, “Santo Daime; betekenis en aantrekkingskracht van een ayahuasca-religie”, is een geredigeerde versie van Wuyts’ afstudeerscriptie. De connectie tussen de Santo Daime in Brazilië en Nederland wordt onder de loep genomen, en wat het boek bijzonder maakt is dat het alleen gebaseerd is op literatuur en interviews – Wuyts heeft zelf niet deelgenomen aan de rituelen. De hoofdvraag die in het boek behandeld wordt is “Wat is de betekenis en aantrekkingskracht van de Santo Daime-religie voor de deelnemers en hoe kan men verklaren dat het in minder dan een eeuw over de hele wereld is verspreid?”

Santo Daime: betekenis en aantrekkingskracht van een ayahuasca-religie, Jazmin Wuyts, gepubliceerd door de auteur. ISBN 978-90-8759-058-1.

Changes in Spirituality Among Ayahuasca Ceremony Novice Participants

June 23, 2009 / Ayahuasca, Mystical experiences, Papers, Psychology, Publications, Religious studies, Spirituality / By / , ,

Abstract

Ayahuasca, a hallucinogenic plant brew from the Amazon basin used as part of healing ceremonies by the local indigenous people of the region for centuries, is now being consumed by growing numbers of people throughout the world. Anecdotal evidence and previous research suggest that there are spiritual effects experienced among participants who take part in ayahuasca ceremonies. The current study examined whether novice participants’ spirituality was affected through participation in an ayahuasca ceremony, and if so, how. A mixed-design method was used, comparing those participating in an ayahuasca ceremony to those who did not participate. This investigation used the Peak Experience Profile, the Spiritual Well-being Scale, and the Mysticism Scale as quantitative measures. Participant interviews and written accounts of ceremony experiences were analyzed. Results showed that neither the SWB score nor the M-Scale score increased significantly after participating in an ayahuasca ceremony. However, it was found that the higher the PEP score, the greater the positive change in SWB and MScale scores. Qualitative data revealed common spiritual themes in many of the participants’ interviews and written accounts. Experiential differences were displayed within the ayahuasca ceremony group, warranting continued investigation into, and identification of, various confounding variables that prompt reported changes in spirituality within some participants while not in others.

Trichter, S., Klimo, J., & Krippner, S. (2009). Changes in Spirituality Among Ayahuasca Ceremony Novice Participants. Journal of Psychoactive Drugs, 41(2), 121-134. http://dx.doi.org/10.1080/02791072.2009.10399905
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The Neurochemical Effects of Harmine in Animal Models of Depression

April 26, 2009 / Ayahuasca, Depression, Other substances, Papers, Psychiatry, Psychology, Psychopharmacology, Publications / By /

Abstract

Harmine is a β-carboline that acts on the CNS, by inhibiting the enzyme monoamine oxidase type A-MAO. This alkaloid binds with affinity to receptors on serotonin as 5-hydroxytryptamine, 5-HT2C subtypes and 5-HT2A receptors and imidazole (I2). The objective of this study was to investigate the physiological and behavioral effects of acute and chronic administration of harmine (5, 10 and 15 mg / kg) and imipramine (10, 20 and 30 mg / kg) using the forced swimming test (TNF) and the protocol of chronic mild stress (ECM) in an animal model. The results showed that rats treated acutely and chronically with harmine and imipramine reduced the immobility time in the TNF, and increased both climbigns and swimming time of rats compared to saline group, without affecting locomotor activity in the open field test. Both acute and chronic administration of harmine increased factor brain-derived neurotrophic (BDNF) protein levels in the rat hippocampus. Our findings demonstrated that chronic stressful situations induced anhedonia, hypertrophy of adrenal gland weight, increase ACTH circulating levels in rats and increase BDNF protein levels. Interestingly, treatment with harmine for 7 consecutive days, reversed anhedonia, the increase of adrenal gland weight, normalized ACTH circulating levels and BDNF protein levels. Finally, these findings further support the hypothesis that harmine could be a new pharmacological tool for the treatment of depression.

Fortunato, J. J. 2009. The Neurochemical Effects of Harmine in Animal Models of Depression. PhD thesis.
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When the Endogenous Hallucinogenic Trace Amine N,N-Dimethyltryptamine Meets the Sigma-1 Receptor

March 10, 2009 / DMT, Other subjects, Papers, Psychopharmacology, Publications / By / , ,

Abstract

N,N-dimethyltryptamine (DMT) is a hallucinogen found endogenously in human brain that is commonly recognized to target the 5-hydroxytryptamine 2A receptor or the trace amine–associated receptor to exert its psychedelic effect. DMT has been recently shown to bind sigma-1 receptors, which are ligand-regulated molecular chaperones whose function includes inhibiting various voltage-sensitive ion channels. Thus, it is possible that the psychedelic action of DMT might be mediated in part through sigma-1 receptors. Here, we present a hypothetical signaling scheme that might be triggered by the binding of DMT to sigma-1 receptors.

Su, T., Hayashi, T., & Vaupel, D. B. (2009). When the Endogenous Hallucinogenic Trace Amine N,N-Dimethyltryptamine Meets the Sigma-1 Receptor. Science Signaling, 2(61). http://dx.doi.org/10.1126/scisignal.261pe12
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How could MDMA (ecstasy) help anxiety disorders? A neurobiological rationale

March 9, 2009 / Anxiety disorders / PTSD, MDMA, Neuroscience, Papers, Psychiatry, Psychology, Psychopharmacology, Psychotherapy, Publications / By / ,

Abstract

Exposure therapy is known to be an effective treatment for anxiety disorders. Nevertheless, exposure is not used as much as it should be, and instead patients are often given supportive medications such as serotonin reuptake inhibitors (SSRIs) and benzodiazepines, which may even interfere with the extinction learning that is the aim of treatment. Given that randomized controlled trials are now investigating a few doses of ±3,4-methylenedioxymethamphetamine (MDMA, ‘ecstasy’) in combination with psychotherapy for treatment-resistant anxiety disorders, we would like to suggest the following three mechanisms for this potentially important new approach: 1) MDMA increases oxytocin levels, which may strengthen the therapeutic alliance; 2) MDMA increases ventromedial prefrontal activity and decreases amygdala activity, which may improve emotional regulation and decrease avoidance and 3) MDMA increases norepinephrine release and circulating cortisol levels, which may facilitate emotional engagement and enhance extinction of learned fear associations. Thus, MDMA has a combination of pharmacological effects that, in a therapeutic setting, could provide a balance of activating emotions while feeling safe and in control, as described in case reports of MDMA-augmented psychotherapy. Further clinical and preclinical studies of the therapeutic value of MDMA are indicated.

Johansen, P. Ø., & Krebs, T. S. (2009). How could MDMA (ecstasy) help anxiety disorders? A neurobiological rationale. Journal of Psychopharmacology, 23(4), 389-391. http://dx.doi.org/10.1177/0269881109102787
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Afkicken met iboga

February 19, 2009 / OPEN Lectures / By

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Op dit moment wordt er veel onderzoek verricht naar de “verslavings-onderbrekende” stof ibogaïne, afkomstig uit de Tabernanthe iboga boom. Ben de Loenen is expert geworden op dit gebied nadat hij de documentaire “Iboga: Rite of Passage” heeft gemaakt. In deze lezing laat hij de feiten zien over de toepassing van ibogaïne in de verslavingszorg.

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Gaddum and LSD: the birth and growth of experimental and clinical neuropharmacology research on 5-HT in the UK

January 29, 2009 / Depression, LSD, Medicine, Neuroscience, Other subjects, Other substances, Papers, Psychopharmacology, Psychotherapy, Publications / By /

Abstract

The vasoconstrictor substance named serotonin was identified as 5-hydroxytryptamine (5-HT) by Maurice Rapport in 1949. In 1951, Rapport gave Gaddum samples of 5-HT substance allowing him to develop a bioassay to both detect and measure the amine. Gaddum and colleagues rapidly identified 5-HT in brain and showed that lysergic acid diethylamide (LSD) antagonized its action in peripheral tissues. Gaddum accordingly postulated that 5-HT might have a role in mood regulation. This review examines the role of UK scientists in the first 20 years following these major discoveries, discussing their role in developing assays for 5-HT in the CNS, identifying the enzymes involved in the synthesis and metabolism of 5-HT and investigating the effect of drugs on brain 5-HT. It reviews studies on the effects of LSD in humans, including Gaddum’s self-administration experiments. It outlines investigations on the role of 5-HT in psychiatric disorders, including studies on the effect of antidepressant drugs on the 5-HT concentration in rodent and human brain, and the attempts to examine 5-HT biochemistry in the brains of patients with depressive illness. It is clear that a rather small group of both preclinical scientists and psychiatrists in the UK made major advances in our understanding of the role of 5-HT in the brain, paving the way for much of the knowledge now taken for granted when discussing ways that 5-HT might be involved in the control of mood and the idea that therapeutic drugs used to alleviate psychiatric illness might alter the function of cerebral 5-HT.

Green, A. R. (2008). Gaddum and LSD: the birth and growth of experimental and clinical neuropharmacology research on 5‐HT in the UK. British journal of pharmacology, 154(8), 1583-1599., 10.1038/bjp.2008.207
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Endogenous hallucinogens as ligands of the trace amine receptors: A possible role in sensory perception

January 14, 2009 / DMT, Other subjects, Other substances, Papers, Psychopharmacology, Publications / By /

Abstract

While the endogenous hallucinogens, N,N-dimethyltryptamine, 5-hydroxy-N,N-dimethyl-tryptamine and 5-methoxy-N,N-dimethyltryptamine, have been acknowledged as naturally occurring components of the mammalian body for decades, their biological function remains as elusive now as it was at the time of their discovery. The recent discovery of the trace amine associated receptors and the activity of DMT and other hallucinogenic compounds at these receptor sites leads to the hypothesis that the endogenous hallucinogens act as neurotransmitters of a subclass of these trace amine receptors. Additionally, while activity at the serotonin 5-HT2A receptor has been proposed as being responsible for the hallucinogenic affects of administered hallucinogens, in their natural setting the 5-HT2A receptor may not interact with the endogenous hallucinogens at all. Additionally 5-HT2A agonist activity is unable to account for the visual altering effects of many of the administered hallucinogens; these effects may be mediated by one of the endogenous hallucinogen trace amine receptors rather than the serotonin 5-HT2A receptor. Therefore, activity at the trace amine receptors, in addition to serotonin receptors, may play a large role in the sensory altering effects of administered hallucinogens and the trace amine receptors along with their endogenous hallucinogen ligands may serve an endogenous role in mediating sensory perception in the mammalian central nervous system. Thus the theory proposed states that these compounds act as true endogenous hallucinogenic transmitters acting in regions of the central nervous system involved in sensory perception.

Wallach, J. V. (2009). Endogenous hallucinogens as ligands of the trace amine receptors: A possible role in sensory perception. Medical Hypotheses, 72(1), 91–94. http://dx.doi.org/10.1016/j.mehy.2008.07.052
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Gas chromatographic analysis of dimethyltryptamine and beta-carboline alkaloids in ayahuasca, an Amazonian psychoactive plant beverage

January 12, 2009 / Ayahuasca, Chemistry, Other subjects, Papers, Publications / By / , , , , ,

Abstract

Introduction: Ayahuasca is obtained by infusing the pounded stems of Banisteriopsis caapi in combination with the leaves of Psychotria viridis. P. viridis is rich in the psychedelic indole N,N-dimethyltryptamine, whereas B. caapi contains substantial amounts of β-carboline alkaloids, mainly harmine, harmaline and tetrahydroharmine, which are monoamine-oxidase inhibitors. Because of differences in composition in ayahuasca preparations, a method to measure their main active constituents is needed.

Objective: To develop a gas chromatographic method for the simultaneous determination of dimethyltryptamine and the main β-carbolines found in ayahuasca preparations.

Methodology: The alkaloids were extracted by means of solid phase extraction (C18) and detected by gas chromatography with nitrogen/phosphorous detector.

Results: The lower limit of quantification (LLOQ) was 0.02 mg/mL for all analytes. The calibration curves were linear over a concentration range of 0.02–4.0 mg/mL (r2 > 0.99). The method was also precise (RSD < 10%).

Conclusion: A simple gas chromatographic method to determine the main alkaloids found in ayahuasca was developed and validated. The method can be useful to estimate administered doses in animals and humans for further pharmacological and toxicological investigations of ayahuasca.

Pires, A. P. S., De Oliveira, C. D. R., Moura, S., Dörr, F. A., Silva, W. A. E., & Yonamine, M. (2009). Gas chromatographic analysis of dimethyltryptamine and β‐carboline alkaloids in ayahuasca, an amazonian psychoactive plant beverage. Phytochemical Analysis, 20(2), 149-153. 10.1002/pca.1110
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