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Crisis Intervention Related to the Use of Psychoactive Substances in Recreational Settings – Evaluating the Kosmicare Project at Boom Festival

Abstract

Kosmicare project implements crisis intervention in situations related to the use of psychoactive substances at Boom Festival (Portugal). We present evaluation research that aims to contribute to the transformation of the project into an evidence-based intervention model. It relies on harm reduction and risk minimization principles, crisis intervention models, and Grof’s psychedelic psychotherapy approach for crisis intervention in situations related to unsupervised use of psychedelics. Intervention was expected to produce knowledge about the relation between substance use and mental health impact in reducing potential risk related to the use of psychoactive substances and mental illness, as well as an impact upon target population’s views of themselves, their relationship to substance use, and to life events in general. Research includes data on process and outcome indicators through a mixed methods approach, collected next to a sample of n=176 participants. Sample size varied considerably, however, among different research measures. 52% of Kosmicare visitors reported LSD use. Over 40% also presented multiple drug use. Pre-post mental state evaluation showed statistically significant difference (p<.05) confirming crisis resolution. Crisis episodes that presented no resolution were more often related with mental health outburst episodes, with psychoactive substance use or not. Visitors showed high satisfaction with intervention (n=58) and according to follow-up (n=18) this perception was stable over time. Crisis intervention was experienced as very significant. We discuss limitations and implications of evaluating natural setting based interventions, and the relation between psychoactive substance use and psychopathology. Other data on visitor’s profile and vulnerability to crisis showed inconclusive.

Carvalho, M. C., de Sousa, M. P., Frango, P., Dias, P., Carvalho, J., Rodrigues, M., & Rodrigues, T. (2015). Crisis Intervention Related to the Use of Psychoactive Substances in Recreational Settings-Evaluating the Kosmicare Project at Boom Festival. Current Drug Abuse Reviews, 7(2), 81-100. https://dx.doi.org/10.2174/1874473708666150107115515

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Psychedelics as Medicines for Substance Abuse Rehabilitation: Evaluating Treatments with LSD, Peyote, Ibogaine and Ayahuasca

Abstract

Substances known as psychedelics, hallucinogens and entheogens have been employed in ethnomedical traditions for thousands of years, but after promising uses in the 1950’s and 1960’s they were largely prohibited in medical treatment and human research starting in the 1970’s as part of the fallout from the war on drugs. Nonetheless, there are a number of studies which suggest that these substances have potential applications in the treatment of addictions. While these substances are generally classified as Schedule I, alleging no established medical uses and a high drug abuse potential, there is nonetheless evidence indicating they might be safe and effective tools for short term interventions in addictions treatment. Evidence suggests that the psychedelics have a much greater safety profile than the major addictive drugs, having extremely low levels of mortality, and producing little if any physical dependence. This paper reviews studies evaluating the use of LSD, peyote, ibogaine and ayahuasca in the treatment of dependencies and the possible mechanisms underlying the indications of effectiveness. Evidence suggests that these substances help assist recovery from drug dependency through a variety of therapeutic mechanisms, including a notable “after-glow” effect that in part reflects their action on the serotonin neurotransmitter system. Serotonin has been long recognized as central to the psychedelics’ well-known phenomenological, physical, emotional and cognitive dynamics. These serotonin-based dynamics are directly relevant to treatment of addiction because of depressed serotonin levels found in addict populations, as well as the role of serotonin as a neuromodulators affecting many other neurotransmitter systems.

Winkelman, M. (2015). Psychedelics as Medicines for Substance Abuse Rehabilitation: Evaluating Treatments with LSD, Peyote, Ibogaine and Ayahuasca. Current Drug Abuse Reviews, 7(2), 101-116. https://dx.doi.org/10.2174/1874473708666150107120011

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A Qualitative Report on the Subjective Experience of Intravenous Psilocybin Administered in an fMRI Environment

Abstract

Background: This report documents the phenomenology of the subjective experiences of 15 healthy psychedelic experienced volunteers who were involved in a functional magnetic resonance imaging (fMRI) study that was designed to image the brain effects of intravenous psilocybin.

Methods: The participants underwent a semi-structured interview exploring the effects of psilocybin in the MRI scanner. These interviews were analysed by Interpretative Phenomenological Analysis. The resultant data is ordered in a detailed matrix, and presented in this paper.

Results: Nine broad categories of phenomenology were identified in the phenomenological analysis of the experience; perceptual changes including visual, auditory and somatosensory distortions, cognitive changes, changes in mood, effects of memory, spiritual or mystical type experiences, aspects relating to the scanner and research environment, comparisons with other experiences, the intensity and onset of effects, and individual interpretation of the experience.

Discussion: This article documents the phenomenology of psilocybin when given in a novel manner (intravenous injection) and setting (an MRI scanner). The findings of the analysis are consistent with previous published work regarding the subjective effects of psilocybin. There is much scope for further research investigating the phenomena identified in this paper.

Turton, S., Nutt, D. J., & Carhart-Harris, R. L. (2015). A Qualitative Report on the Subjective Experience of Intravenous Psilocybin Administered in an fMRI Environment. Current Drug Abuse Reviews, 7(2), 117-127. https://dx.doi.org/10.2174/1874473708666150107120930
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Salvinorin A and Related Compounds as Therapeutic Drugs for Psychostimulant-Related Disorders

Abstract

Pharmacological treatments are available for alcohol, nicotine, and opioid dependence, and several drugs for cannabis-related disorders are currently under investigation. On the other hand, psychostimulant abuse and dependence lacks pharmacological treatment. Mesolimbic dopaminergic neurons mediate the motivation to use drugs and drug-induced euphoria, and psychostimulants (cocaine, amphetamine, and methamphetamine) produce their effects in these neurons, which may be modulated by the opioid system. Salvinorin A is a κ-opioid receptor agonist extracted from Salvia divinorum, a hallucinogenic plant used in magico-ritual contexts by Mazateca Indians in México. Salvinorin A and its analogues have demonstrated anti-addiction effects in animal models using psychostimulants by attenuating dopamine release, sensitization, and other neurochemical and behavioral alterations associated with acute and prolonged administration of these drugs. The objective of the present article is to present an overview of the preclinical evidence suggesting anti-addictive effects of salvinorin A and its analogues.

dos Santos, R. G., Crippa, J. A., Machado-de-Sousa, J. P., & Hallak, J. E. (2015). Salvinorin A and Related Compounds as Therapeutic Drugs for Psychostimulant-Related Disorders. Current Drug Abuse Reviews, 7(2), 128-132. https://dx.doi.org/10.2174/1874473708666150107122741

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A Different Medicine, Postcolonial Healing in the Native American Church

A Different Medicine, Postcolonial Healing in the Native American Church, Joseph D. Calabrese, Oxford University Press, 2013

This study is the result of two years of fieldwork with the Navajo in New Mexico. The author has both an anthropological and a clinical background, and combined one year of fieldwork with work in a clinic aimed at supporting young Native Americans with a drug and/or alcohol problem. This unique combination of anthropology and clinical psychology results in a ‘clinical ethnography’, in which the author analyses the use of peyote within the Native American Church. He examines, on the one hand, the place that peyote holds within the culture and the symbolism of the ritual, and on the other hand its use within a clinical treatment that supports young people in defeating their addiction with the help of rituals.

The first part of the book, about one third of the whole, is devoted to methodology and the theoretical underpinning that is necessary to observe the healing practices of cultures different from one’s own. For non-anthropologists this is quite enlightening, because it clearly shows the problems a researcher is confronted with when the cultural practices differ strongly from those he or she is used to. The most important subjects that are discussed in this part are the dangers of ethnocentrism and the necessity of self-reflection, but this discussion also provides some exciting ideas that stretch our understanding of therapy itself. The emphasis on how therapy is embedded in the culture and mythology of a group of people simultaneously raises the question whether and how this happens within our own culture.

Calabrese states that within Navajo culture (and many other traditional cultures that use psychoactive substances within their rituals) the concepts psychopharmacology and psychology do not exist and that the Navajo do not think in terms of these two different fields of science. The symbolism of the rituals is also connected to the broader cultural mythology, through which the healing process is embedded within a wider cultural narrative applicable to all members of this culture. In the West this so-called therapeutic ‘emplotment’ is often aimed at a scientific model of the psyche, or at a personal story that gives direction in the healing process.

By becoming aware of our cultural prejudices through a dialectic with other cultures, we can learn to better understand others and ourselves. Calabrese supports this idea by writing texts that engender empathy and thereby induce a better understanding of the other and therefore of ourselves. By focusing his research on the use of psychoactive substances within a healing ritual that is at the same time spiritual, Calabrese intends to demonstrate that current views on the use of such substances are in need of revision. Instead of focusing on who takes which substance, he pleads in favor of examining the way in which such substances are used within a broader cultural context, and asking the question whether or not this is useful or healing.

In the second part Calabrese further analyzes the symbolism in the rituals of the Native American Church. First he discusses the history of this church and the way in which it has been misunderstood time and again (as a heathen ritual or as an excuse for drug use). He goes on to successively elaborate the view on peyote held by members of the church, the nature of the ceremony and the role the church plays in socialization and the creation of community ties. Lastly, he describes the way in which ceremonies are embedded within Native American mental healthcare.

The members of the church see peyote both as a medicine and as a spirit. Some emphasize the medicinal aspect, others the spiritual aspects, so that no uniform understanding can be identified. Calabrese also notes the personal relation people have with peyote and thereby confirms that personal interpretations remain possible. These interpretations partly fit within the broader (not exclusively Native American Church affiliated) Navajo culture, and partly they are unique to this church.

The ceremony itself is aimed at healing, and the ritual supports this process by means of the various symbols that are central to it. By reflecting on these symbols, communicating with the medicine or the spirit of peyote, and through the transformative power of the experience, the members of the church see their own life in the light of the mythology of death and rebirth within which their healing becomes meaningful. The therapeutic process focuses less on the relation between therapist and patient and more on the personal relationship a person engages in with the medicine within the ritual context.

The members of the church also see the ceremonies as a form of socialization, where family ties and friendships are strengthened. Children are introduced at an early age if they show interest. There is a lot of resistance against this within Western/Christian culture, but Calabrese shows that after several decades of these practices it still hasn’t been proven that such use of peyote by young people within the context of the church has any negative consequences. Peyote is seen as a force that helps strengthen relations and stimulates one to live an ethical life. It also plays a role in the upbringing and development of young Navajo’s. For example, there are special ceremonies to support them in the challenges they face in their regular education, where the group prays for help and guidance.

The Native American Church ceremony has even earned a place in the officially approved treatment methods for young people that have a problematic drug use. This is in sharp contrast with the fact that peyote is officially scheduled as a substance without any medical application. Calabrese has observed in his work at the clinic how the ritual helped support young adults with such problems in their healing process, and simultaneously notes that, because of the official approval of the use of peyote, bureaucracy has shaped the ritual itself. For example, it is required to be aimed at the treatment of addiction in one or more young adults instead of a more general ritual as in the regular church services.

With this book, Calabrese argues for a cultural pluralism within mental healthcare. By connecting patients to rituals and practices from their own cultural backgrounds, a valuable aspect of their healing process is addressed. By participating in peyote ceremonies, young people with substance abuse problems are shown a valuable example of how to use substances in a way that is not destructive, and in many cases even healing. At the same time it reconnects them to their parents and family and restores the ties that have been broken. By acknowledging that there are different ways that can help within a healing process, Calabrese exposes the hegemonic cultural ethnocentrism and the ideological prejudices that often prevent us from thinking clearly about the traditional use of psychoactive substances in different cultures.

In summary this book is an excellent addition to the existing literature on the Native American Church, especially because it tries to acknowledge and circumvent existing cultural prejudices, in order to engender an analysis rooted in mutual respect. This is not only important for the use of a powerful psychedelic substance, but also to bring to light the negative impact of colonialism and to envision a world in which the pain that is still alive among Native Americans can be healed and overcome.

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Classic psychedelic use is associated with reduced psychological distress and suicidality

A8_thumbnail_500x400In a population-based survey study that was published earlier this month, an association was found between the use of classic psychedelics and reduced psychological distress and suicidality [fusion_builder_container hundred_percent=”yes” overflow=”visible”][fusion_builder_row][fusion_builder_column type=”1_1″ background_position=”left top” background_color=”” border_size=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none”][1]. The researchers included the data of 191.382 individuals that participated in the annual National Survey on Drug Use and Health (NSDUH) [2] between 2008 and 2012, and made a comparison between the psychological well being of classic psychedelic users and non-users. Classic psychedelic users were categorized as such if they met the criteria of having used ayahuasca, mescaline, LSD, peyote or San Pedro and/or psilocybin at least once in their lifetime. To rule out the possibility that differences between the groups of users and non-users could be attributed to factors other than classic psychedelics, the researchers statistically controlled the demographical factors age, gender, ethno-racial identity, educational attainment, annual household income, marital status, self-reported risky behavior and lifetime illicit drug use. No solid claim can be made about causality from this correlation, but the results are in line with earlier hypotheses that the effects of psychedelics may have qualities that could be helpful in modulating suicide risk [3]. As a current estimate, about 7% of the population worldwide suffers from mental health disorders [4]. The results of this study are a hopeful answer to the request from the National Action Alliance for Suicide Prevention (2014) to develop novel interventions that aim at suicide prevention.


 
[1] Hendricks et al. (2015).
[2] The NSDUH survey is the annual survey that is conducted by the United States Department of Health and Human Services. The survey aims at estimating the prevalence of substance use and mental illnesses.
[3] An extensive overview of earlier research can be found in the third and fourth paragraph of the article of Hendricks et al. (2015).
[4] This is based on the estimate of the World Health Organization (2001) that about half a billion people worldwide experience mental health problems and that the current world population is estimated at 7.2 billion (United States Census Bureau, 2015)
 
References

Hendricks, P. S., Thorne, C. B., Clark, C. B., Coombs, D. W., & Johnson, M. W. (2015). Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. Journal of Psychopharmacology. [Abstract]
National Action Alliance for Suicide Prevention: Research Prioritization Task Force (2014). A prioritized research agenda for suicide prevention: An action plan to save lives. National Institute of Mental Health and the Research Prioritization Task Force, Rockville, Maryland.
United States Census Bureau (2015). U.S. and World Population Clock. As retrieved on January 17. from http://www.census.gov/popclock/
World Health Organization (2001). The World health report 2001: Mental health: New understanding, new hope. Geneva, Switzerland: World Health Organization[/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]

Long-term use of psychedelic drugs is associated with differences in brain structure and personality in humans

Abstract

Psychedelic agents have a long history of use by humans for their capacity to induce profound modifications in perception, emotion and cognitive processes. Despite increasing knowledge of the neural mechanisms involved in the acute effects of these drugs, the impact of sustained psychedelic use on the human brain remains largely unknown. Molecular pharmacology studies have shown that psychedelic 5-hydroxytryptamine (5HT)2A agonists stimulate neurotrophic and transcription factors associated with synaptic plasticity. These data suggest that psychedelics could potentially induce structural changes in brain tissue. Here we looked for differences in cortical thickness (CT) in regular users of psychedelics. We obtained magnetic resonance imaging (MRI) images of the brains of 22 regular users of ayahuasca (a preparation whose active principle is the psychedelic 5HT2A agonist N,N-dimethyltryptamine (DMT)) and 22 controls matched for age, sex, years of education, verbal IQ and fluid IQ. Ayahuasca users showed significant CT differences in midline structures of the brain, with thinning in the posterior cingulate cortex (PCC), a key node of the default mode network. CT values in the PCC were inversely correlated with the intensity and duration of prior use of ayahuasca and with scores on self-transcendence, a personality trait measuring religiousness, transpersonal feelings and spirituality. Although direct causation cannot be established, these data suggest that regular use of psychedelic drugs could potentially lead to structural changes in brain areas supporting attentional processes, self-referential thought, and internal mentation. These changes could underlie the previously reported personality changes in long-term users and highlight the involvement of the PCC in the effects of psychedelics.

Bouso, J. C., Palhano-Fontes, F., Rodríguez-Fornells, A., Ribeiro, S., Sanches, R., Crippa, J. A. S., … & Riba, J. (2015). Long-term use of psychedelic drugs Is associated with differences in brain structure and personality in humans. European Neuropsychopharmacology. http://dx.doi.org/10.1016/j.euroneuro.2015.01.008
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Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population

Abstract

Mental health problems are endemic across the globe, and suicide, a strong corollary of poor mental health, is a leading cause of death. Classic psychedelic use may occasion lasting improvements in mental health, but the effects of classic psychedelic use on suicidality are unknown. We evaluated the relationships of classic psychedelic use with psychological distress and suicidality among over 190,000 USA adult respondents pooled from the last five available years of the National Survey on Drug Use and Health (2008–2012) while controlling for a range of covariates. Lifetime classic psychedelic use was associated with a significantly reduced odds of past month psychological distress (weighted odds ratio (OR)=0.81 (0.72–0.91)), past year suicidal thinking (weighted OR=0.86 (0.78–0.94)), past year suicidal planning (weighted OR=0.71 (0.54–0.94)), and past year suicide attempt (weighted OR=0.64 (0.46–0.89)), whereas lifetime illicit use of other drugs was largely associated with an increased likelihood of these outcomes. These findings indicate that classic psychedelics may hold promise in the prevention of suicide, supporting the view that classic psychedelics’ most highly restricted legal status should be reconsidered to facilitate scientific study, and suggesting that more extensive clinical research with classic psychedelics is warranted.

Hendricks, P. S., Thorne, C. B., Clark, C. B., Coombs, D. W., & Johnson, M. W. (2015). Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. Journal of Psychopharmacology. https://dx.doi.org/10.1177/0269881114565653

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Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study

Abstract

Several lines of evidence suggest that classic (5HT2A agonist) hallucinogens have clinically relevant effects in alcohol and drug addiction. Although recent studies have investigated the effects of psilocybin in various populations, there have been no studies on the efficacy of psilocybin for alcohol dependence. We conducted a single-group proof-of-concept study to quantify acute effects of psilocybin in alcohol-dependent participants and to provide preliminary outcome and safety data. Ten volunteers with DSM-IV alcohol dependence received orally administered psilocybin in one or two supervised sessions in addition to Motivational Enhancement Therapy and therapy sessions devoted to preparation for and debriefing from the psilocybin sessions. Participants’ responses to psilocybin were qualitatively similar to those described in other populations. Abstinence did not increase significantly in the first 4 weeks of treatment (when participants had not yet received psilocybin), but increased significantly following psilocybin administration (p < 0.05). Gains were largely maintained at follow-up to 36 weeks. The intensity of effects in the first psilocybin session (at week 4) strongly predicted change in drinking during weeks 5–8 (r = 0.76 to r = 0.89) and also predicted decreases in craving and increases in abstinence self-efficacy during week 5. There were no significant treatment-related adverse events. These preliminary findings provide a strong rationale for controlled trials with larger samples to investigate efficacy and mechanisms.

Bogenschutz, M. P., Forcehimes, A. A, Pommy, J. A., Wilcox, C. E., Barbosa, P. C. R., & Strassman, R. J. (2015). Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study. Journal of Psychopharmacology. https://dx.doi.org/10.1177/0269881114565144

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Making a medicine out of MDMA

Abstract

From its first use 3,4,-methylenedioxymethamphetamine (MDMA) has been recognised as a drug with therapeutic potential. Research on its clinical utility stopped when it entered the recreational drug scene but has slowly resurrected in the past decade. Currently there is enough evidence for MDMA to be removed from its Schedule 1 status of ‘no medical use’ and moved into Schedule 2 (alongside other misused but useful medicines such as heroin and amphetamine). Such a regulatory move would liberate its use as a medicine for patients experiencing severe mental illnesses such as treatment-resistant post-traumatic stress disorder.

Sessa, B., & Nutt, D. (2015). Making a medicine out of MDMA. The British Journal of Psychiatry, 206, 4-6. https://dx.doi.org/10.1192/bjp.bp.114.152751

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