OPEN Foundation

OPEN Foundation

In Memory of Andrew Sewell

The sad news has reached us that Andrew Sewell passed away on Sunday July 21st while he was recovering from surgery. R. Andrew Sewell, MD, was assistant professor of Psychiatry at Yale University where he conducted fascinating research on psyche

delics. We had the pleasure of meeting Andrew at our 2010 Mind Altering Science Conference, where he presented his research as one of our invited speakers.

We will remember Andrew Sewell as a cheerful, optimistic and talented researcher with a gift for inspiring others through his lectures. We feel that his passing away is a great loss for the psychedelic research community. Our deepest sympathies go out to Andrew’s friends and family.

Among other things, Andrew was responsible for writing the well read and sobering manual on how to become a psychedelic researcher, entitled ‘So you want to become a psychedelic researcher?’, a must read for aspiring scientists wanting to study psychedelic substances.

Thank you Andrew, for your contributions to psychedelic research and for your inspiring lectures, filled to the brim with information, delivered at high speed. You’ll be missed.

Confrontation with the Unconscious: Jungian Depth Psychology and Psychedelic Experience

confrontationCarl Gustav Jung pioneered the transformative potential of the deep unconscious. Psychedelic substances provide direct and powerful access to this inner world. How, then, might Jungian psychology help us to better understand the nature of psychedelic experiences? And how might psychedelics assist the movement toward psychological transformation described by Jung?

Jungian depth psychology and psychedelic psychotherapy are both concerned with coming to terms with unconscious drives, complexes, and symbolic images. Unaware of significant evidence for the safe clinical use of psychedelic drugs, Jung himself remained wary of psychedelics and staunchly opposed their therapeutic use. His bias has prevented Jungians from objectively considering the benefits as well as the risks of using psychedelics for psychological healing and growth.

Confrontation with the Unconscious intertwines psychedelic research, personal accounts of psychedelic experiences, and C. G. Jung’s work on trauma, the shadow, psychosis, and psychospiritual transformation — including Jung’s own “confrontation with the unconscious” — to show the relevance of Jung’s penetrating insights to the work of Stanislav Grof, Ann Shulgin, Ronald Sandison, Margot Cutner, among other psychedelic and transpersonal researchers, and to demonstrate the great value of Jung’s penetrating insights for understanding difficult psychedelic experiences and promoting safe and effective psychedelic exploration and psychotherapy.

Scott J. Hill, Ph. D., lives in Sweden, where he conducts scholarly research on the intersection between psychedelic studies and Jungian psychology. He holds degrees in psychology from the University of Minnesota and in philosophy and religion from the California Institute of Integral Studies.

Confrontation with the Unconscious: Jungian Depth Psychology and Psychedelic Experience, by Scott J. Hill, Muswell Hill Press, 252 pages.
Buy this book at bookdepository.com and support the OPEN Foundation.

Confrontation with the Unconscious: Jungian Depth Psychology and Psychedelic Experience

Carl Gustav Jung pioneered the transformative potential of the deep unconscious. Psychedelic substances provide direct and powerful access to this inner world. How, then, might Jungian psychology help us to better understand the nature of psychedelic experiences? And how might psychedelics assist the movement toward psychological transformation described by Jung?

Jungian depth psychology and psychedelic psychotherapy are both concerned with coming to terms with unconscious drives, complexes, and symbolic images. Unaware of significant evidence for the safe clinical use of psychedelic drugs, Jung himself remained wary of psychedelics and staunchly opposed their therapeutic use. His bias has prevented Jungians from objectively considering the benefits as well as the risks of using psychedelics for psychological healing and growth.

Confrontation with the Unconscious intertwines psychedelic research, personal accounts of psychedelic experiences, and C. G. Jung’s work on trauma, the shadow, psychosis, and psychospiritual transformation — including Jung’s own “confrontation with the unconscious” — to show the relevance of Jung’s penetrating insights to the work of Stanislav Grof, Ann Shulgin, Ronald Sandison, Margot Cutner, among other psychedelic and transpersonal researchers, and to demonstrate the great value of Jung’s penetrating insights for understanding difficult psychedelic experiences and promoting safe and effective psychedelic exploration and psychotherapy.

Scott J. Hill, Ph. D., lives in Sweden, where he conducts scholarly research on the intersection between psychedelic studies and Jungian psychology. He holds degrees in psychology from the University of Minnesota and in philosophy and religion from the California Institute of Integral Studies.

Confrontation with the Unconscious: Jungian Depth Psychology and Psychedelic Experience, door Scott J. Hill, Muswell Hill Press, 252 pagina’s.

Koop dit boek via bookdepository.com en steun daarmee Stichting OPEN.

A Different Medicine: Postcolonial Healing in the Native American Church

adifferentmedicineDrawing on two years of ethnographic field research among the Navajos, this book explores a controversial Native American ritual and healthcare practice: ceremonial consumption of the psychedelic Peyote cactus in the context of an indigenous postcolonial healing movement called the Native American Church (NAC), which arose in the 19th century in response to the creation of the reservations system and increasing societal ills, including alcoholism. The movement is the locus of cultural conflict with a long history in North America, and stirs very strong and often opposed emotions and moral interpretations. Joseph Calabrese describes the Peyote Ceremony as it is used in family contexts and federally funded clinical programs for Native American patients. He uses an interdisciplinary methodology that he calls clinical ethnography: an approach to research that involves clinically informed and self-reflective immersion in local worlds of suffering, healing, and normality. Calabrese combined immersive fieldwork among NAC members in their communities with a year of clinical work at a Navajo-run treatment program for adolescents with severe substance abuse and associated mental health problems. There he had the unique opportunity to provide conventional therapeutic intervention alongside Native American therapists who were treating the very problems that the NAC often addresses through ritual. Calabrese argues that if people respond better to clinical interventions that are relevant to their society’s unique cultural adaptations and ideologies (as seems to be the case with the NAC), then preventing ethnic minorities from accessing traditional ritual forms of healing may actually constitute a human rights violation.

A Different Medicine: Postcolonial Healing in the Native American Church, by Joseph D. Calabrese, Oxford Ritual Studies series, Oxford University Press, 256 pages.

Read our review of this book
Buy this book on bookdepository.com and support the OPEN Foundation

Spatiotemporal Brain Dynamics of Emotional Face Processing Modulations Induced by the Serotonin 1A/2A Receptor Agonist Psilocybin

Abstract

Emotional face processing is critically modulated by the serotonergic system. For instance, emotional face processing is impaired by acute psilocybin administration, a serotonin (5-HT) 1A and 2A receptor agonist. However, the spatiotemporal brain mechanisms underlying these modulations are poorly understood. Here, we investigated the spatiotemporal brain dynamics underlying psilocybin-induced modulations during emotional face processing. Electrical neuroimaging analyses were applied to visual evoked potentials in response to emotional faces, following psilocybin and placebo administration. Our results indicate a first time period of strength (i.e., Global Field Power) modulation over the 168–189 ms poststimulus interval, induced by psilocybin. A second time period of strength modulation was identified over the 211–242 ms poststimulus interval. Source estimations over these 2 time periods further revealed decreased activity in response to both neutral and fearful faces within limbic areas, including amygdala and parahippocampal gyrus, and the right temporal cortex over the 168–189 ms interval, and reduced activity in response to happy faces within limbic and right temporo-occipital brain areas over the 211–242 ms interval. Our results indicate a selective and temporally dissociable effect of psilocybin on the neuronal correlates of emotional face processing, consistent with a modulation of the top-down control.

Bernasconi, F., Schmidt, A., Pokorny, T., Kometer, M., Seifritz, E., & Vollenweider, F. X. (2013). Spatiotemporal brain dynamics of emotional face processing modulations induced by the serotonin 1A/2A receptor agonist psilocybin. Cerebral Cortex, bht178. 10.1093/cercor/bht178
Link to full text

Relationship of ketamine's antidepressant and psychotomimetic effects in unipolar depression

Abstract

OBJECTIVES:
Ketamine and other NMDA (N-methyl-D-aspartate) antagonists produce fast-acting antidepressant-like effects, although the underlying mechanism is unclear. Furthermore, high affinity NMDA antagonists such as ketamine are associated with psychotomimetic effects. To date the link between the antidepressant and psychotomimetic effects of ketamine has not been explored. We examined the relationship between the antidepressant and psychotomimetic effects of a single ketamine infusion in subjects diagnosed with major depressive disorder.
METHODS:
In a double-blind, cross-over, placebo-controlled, two weeks clinical trial we studied the effects of ketamine (0.54 mg/kg within 30 min) in a group of 27 hospitalized depressive patients.
RESULTS:
Higher intensity of psychotomimetic symptoms, measured using BPRS, during ketamine administration correlated with alleviation in mood ratings during the following week with maximum on day seven. Ketamine was superior to placebo in all visits (day 1, 4, and 7) assessed by MADRS with effect size (Cohen´s d) of 0.62, 0.57, and 0.44 respectively. There was no significant correlation between ketamine and nor-ketamine plasma levels and MADRS score change at any study time point.
CONCLUSION:
The substantial relationship between ketamine’s antidepressant and psychotomimetic effects was found. This relationship could be mediated by the initial steps of ketamine’s action, trough NMDA receptors, shared by both ketamine’s clinical effects.
Sos, P., Klirova, M., Novak, T., Kohutova, B., Horacek, J., & Palenicek, T. (2013). Relationship of ketamine’s antidepressant and psychotomimetic effects in unipolar depression. Neuroendocrinology Letters34(4), 287-293.
Link to full text

Acute effects of ayahuasca on neuropsychological performance: differences in executive function between experienced and occasional users.

Abstract

BACKGROUND:
Ayahuasca, a South American psychotropic plant tea containing the psychedelic 5-HT2A receptor agonist N,N-dimethyltryptamine, has been shown to increase regional cerebral blood flow in prefrontal brain regions after acute administration to humans. Despite interactions at this level, neuropsychological studies have not found cognitive deficits in abstinent long-term users.

OBJECTIVES:
Here, we wished to investigate the effects of acute ayahuasca intake on neuropsychological performance, specifically on working memory and executive function.

METHODS:
Twenty-four ayahuasca users (11 long-term experienced users and 13 occasional users) were assessed in their habitual setting using the Stroop, Sternberg, and Tower of London tasks prior to and following ayahuasca intake.

RESULTS:
Errors in the Sternberg task increased, whereas reaction times in the Stroop task decreased and accuracy was maintained for the whole sample following ayahuasca intake. Interestingly, results in the Tower of London showed significantly increased execution and resolution times and number of movements for the occasional but not the experienced users. Additionally, a correlation analysis including all subjects showed that impaired performance in the Tower of London was inversely correlated with lifetime ayahuasca use.

CONCLUSIONS:
Acute ayahuasca administration impaired working memory but decreased stimulus-response interference. Interestingly, detrimental effects on higher cognition were only observed in the less experienced group. Rather than leading to increased impairment, greater prior exposure to ayahuasca was associated with reduced incapacitation. Compensatory or neuromodulatory effects associated with long-term ayahuasca intake could underlie preserved executive function in experienced users.

Bouso, J. C., Fábregas, J. M., Antonijoan, R. M., Rodríguez-Fornells, A., & Riba, J. (2013). Acute effects of ayahuasca on neuropsychological performance: differences in executive function between experienced and occasional users. Psychopharmacology, 230(3), 415-424. http://dx.doi.org/10.1007/s00213-013-3167-9
Link to full text

Effects of Schedule I drug laws on neuroscience research and treatment innovation

Abstract

Many psychoactive drugs are used recreationally, particularly by young people. This use and its perceived dangers have led to many different classes of drugs being banned under national laws and international conventions. Indeed, the possession of cannabis, 3,4‑methylenedioxy‑N‑methylamphetamine (MDMA; also known as ecstasy) and psychedelics is stringently regulated. An important and unfortunate outcome of the controls placed on these and other psychoactive drugs is that they make research into their mechanisms of action and potential therapeutic uses — for example, in depression and post‑traumatic stress disorder — difficult and in many cases almost impossible.

Nutt, D. J., King, L. A., & Nichols, D. E. (2013). Effects of Schedule I drug laws on neuroscience research and treatment innovation. Nature Reviews Neuroscience, 14, 577-585. http://dx.doi.org/10.1038/nrn3530
Link to full text

2C or not 2C: phenethylamine designer drug review

Abstract

New groups of synthetic “designer drugs” have increased in popularity over the past several years. These products mimic the euphoric effects of other well-known illicit drugs but are advertised as “legal” highs and are sold over the internet, at raves and night clubs, and in head shops. The 2C series drugs are ring-substituted phenethylamines that belong to a group of designer agents similar in structure to 3,4-methylenedioxy-N-methylamphetamine (MDMA, Ecstasy). Understanding the pharmacology and toxicology of these agents is essential in order to provide the best medical care for these patients. This review focuses on the pharmacology, pharmacokinetics, clinical effects, and treatment of 2C drug intoxication based on available published literature. Multiple names under which 2C drugs are sold were identified and tabulated. Common features identified in patients intoxicated with 2Cs included hallucinations, agitation, aggression, violence, dysphoria, hypertension, tachycardia, seizures, and hyperthermia. Patients may exhibit sympathomimetic symptoms or symptoms consistent with serotonin toxicity, but an excited delirium presentation seems to be consistent amongst deaths attributed to 2C drugs; at least five deaths have been reported in the literature in patients intoxicated with 2C drugs. 2C drugs are a group of designer intoxicants, many of which are marketed as legal, but may carry risks that consumers are unaware of. These drugs may be characterized by either serotonergic toxicity or a sympathomimetic toxidrome, but a presentation consistent with excited delirium is consistent amongst the reported 2C-related deaths. Treatment of 2C intoxication is primarily supportive, but immediate action is required in the context of excited delirium, hyperthermia, and seizure activity.

Dean, B. V., Stellpflug, S. J., Burnett, A. M., & Engebretsen, K. M. (2013). 2C or not 2C: phenethylamine designer drug review. Journal of Medical Toxicology, 9(2), 172-178. 10.1007/s13181-013-0295-x
Link to full text

Entheogens, Society & Law – Towards a Politics of Consciousness, Autonomy & Responsibility

41U01VD7AyL._SX340_BO1,204,203,200_Entheogens, Society & Law takes a major step towards a comprehensive understanding of the human condition, elucidating how empathy, meaning and purpose emerge from three intersecting areas of human life: biology, consciousness and culture.

The term “entheogen” designates a class of psychoactive plant and substance uses that have played, and continue to play, an important role as catalysts of experiences of the “divine,” “sacred” or “numinous,” as well as in divination, healing and, more recently, psychotherapy. The authors expand on these ideas, borrowing from a wide range of disciplines — pharmacology, neurology, consciousness research, psychology, semiotics, theology and mythology — and immersing the reader in a radical and empowering exegesis of influential cultural myths such as that of Original Sin. The resulting insights have practical and ethical implications in many areas of contemporary society, including education, mental health, human rights and law.

Much of the literature on psychedelics and altered states of consciousness remains firmly entrenched in the dualistic logic of prohibition discourse. Unfortunately, this detracts from its ability to engage with the broader existential, ethical and humanitarian questions that, the author’s argue, any bona fide religious or therapeutic tradition needs to address. With its focus on ethics, Entheogens, Society & Law pursues a pragmatic inquiry guided by one paramount question: how can individuals take responsibility for their own lives and wrest power and authority from institutions that deprive them of the very liberties, e.g. to explore consciousness and alter mental functioning, upon which the exercise of responsibility is premised? This question leads to a critical examination of contemporary discourses on emergent ‘technologies of the self,’ human rights, the ‘common good’ — and the extents of state interference with the self-defining choices of sovereign individuals.

The theoretical questions raised by the meta-analysis presented here propose the possibility, if not necessity, of addressing the crises of modernity, including problems surrounding drug use, as a series of contingencies generated by the competing interests of individual’s search for a meaningful existence and powerful institutions exercising hegemonic control over what we can and cannot do towards that ends. This ethical inquiry exposes the faulty premises of exercises of authority and power by demonstrating the central role of human consciousness in the generation of values that ultimately define us and determine what we become. This places discussion on the nature of ‘mind-altering substances’ at the heart of contemporary discourses on human rights, offering empowering and inspiring insights into the future of humanity.

Entheogens, Society & Law — Towards a Politics of Consciousness, Autonomy & Responsibility, by Daniel Waterman, Melrose Books, 496 pages.

Read our review of this book
Buy this book at bookdepository.com and support the OPEN Foundation.

interested in becoming a trained psychedelic-assisted therapist?

Indigenous Talk: Fulni-ô Culture & Jurema - Online Event - Dec 12th