OPEN Foundation

Humanities & Art

Darwin’s Pharmacy: Sex, Plants, and the Evolution of the Noösphere (In Vivo)

Darwin’s Pharmacy: Sex, Plants, and the Evolution of the Noösphere (In Vivo) by Richard M. Doyle, University of Washington Press, 2011.

In his book ‘Darwin’s Pharmacy: Sex, Plants, and the Evolution of the Noösphere (In Vivo)’, Penn State English professor Richard Doyle weaves an intricate argument that challenges some of our scientific presuppositions, like intentionality, evolution and language. He carefully analyses the influence psychedelics can have on perception and suggests an almost Copernican revolution. If we find the spiritual peak experiences evoked by plants and fungi function as “eloquence adjuncts”, and in turn we help these “bringers of beauty” reproduce, then whose intelligence can be said to influence whom?

Writing about trip reports, shamanism and cannabis pornography, Doyle tries to find a language that, like a psychedelic experience, transcends the subject/object dichotomy. His goal is to break down our ordinary way of thinking, so we can form a new perspective. A perspective in which consciousness is always already embedded in an ecological context, which means that everything we experience is dependent on ‘set and setting.’ Doyle seems to be apt when he renames these psychoactives as ‘ecodelics’ because these plants and compounds help us to perceive our interconnection with the ecosystems of our planet.

The result is a rich and challenging book in which form and content are inseparable, and the lines between facts and interpretations get blurred. The blending of his myriad ideas can only be understood in its entirety, which runs the risks that some of his key insights will be overlooked. But for the philosophically inclined reader with an open mind, it’s a well-written book that challenges many assumptions and should be read for that reason alone.

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LSD: a new treatment emerging from the past

Introduction

Psychedelics fell from medical grace nearly half a century ago, but recent activity suggests that some researchers have “high hopes” for their return. 1,2 Over 60 years ago, Albert Hofmann at Sandoz Pharmaceutical Laboratories in Switzerland first synthesized lysergic acid diethylamide (LSD) and personally experienced its effects (later described as a voyage into madness or a chemically induced psychosis) in 1943. Hofmann’s drug opened up a new era of hallucinogenic research. Over the next 15 years, more than a thousand articles on the use of LSD appeared in medical and scientific publications. In 1957, that work gave rise to the term “psychedelic” to describe a mind-manifesting response, described by some as an experience that brought to light matters that had previously been part of the unconscious [fusion_builder_container hundred_percent=”yes” overflow=”visible”][fusion_builder_row][fusion_builder_column type=”1_1″ background_position=”left top” background_color=”” border_size=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none”][…]

Dyck, E. (2015). LSD: a new treatment emerging from the past. CMAJ: Canadian Medical Association journal= journal de l’Association medicale canadienne. https://dx.doi.org/10.1503/cmaj.141358

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Ketamine and Phencyclidine: the good, the bad and the unexpected

Abstract

The history of ketamine and phencyclidine from their development as potential clinical anaesthetics, through drugs of abuse and animal models of schizophrenia to potential rapidly acting antidepressants is reviewed. The discovery in 1983 of the NMDA receptor antagonist property of ketamine and phencyclidine was a key step to understanding their pharmacology, including their psychotomimetic effects in man. This review describes the historical context and the course of that discovery and its expansion into other hallucinatory drugs. The relevance of these findings to modern hypotheses of schizophrenia and the implications for drug discovery are reviewed. The finding of the rapidly acting antidepressant effects of ketamine in man are discussed in relation to other glutamatergic mechanisms.

Lodge, D., & Mercier, M. S. (2015). Ketamine and Phencyclidine: the good, the bad and the unexpected. British journal of pharmacology.  https://dx.doi.org/10.1111/bph.13222
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Psychedelic drugs should be legally reclassified so that researchers can investigate their therapeutic potential

Abstract

Trials of physiologically safe and non-addictive drugs such as LSD are almost impossible, writes James J H Rucker, calling on the authorities to downgrade their unnecessarily restrictive class A, schedule 1 classification.

Rucker, J. J. (2015). Psychedelic drugs should be legally reclassified so that researchers can investigate their therapeutic potential. BMJ, 350, h2902. http://dx.doi.org/10.1136/bmj.h2902
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A Different Medicine, Postcolonial Healing in the Native American Church

A Different Medicine, Postcolonial Healing in the Native American Church, Joseph D. Calabrese, Oxford University Press, 2013

This study is the result of two years of fieldwork with the Navajo in New Mexico. The author has both an anthropological and a clinical background, and combined one year of fieldwork with work in a clinic aimed at supporting young Native Americans with a drug and/or alcohol problem. This unique combination of anthropology and clinical psychology results in a ‘clinical ethnography’, in which the author analyses the use of peyote within the Native American Church. He examines, on the one hand, the place that peyote holds within the culture and the symbolism of the ritual, and on the other hand its use within a clinical treatment that supports young people in defeating their addiction with the help of rituals.

The first part of the book, about one third of the whole, is devoted to methodology and the theoretical underpinning that is necessary to observe the healing practices of cultures different from one’s own. For non-anthropologists this is quite enlightening, because it clearly shows the problems a researcher is confronted with when the cultural practices differ strongly from those he or she is used to. The most important subjects that are discussed in this part are the dangers of ethnocentrism and the necessity of self-reflection, but this discussion also provides some exciting ideas that stretch our understanding of therapy itself. The emphasis on how therapy is embedded in the culture and mythology of a group of people simultaneously raises the question whether and how this happens within our own culture.

Calabrese states that within Navajo culture (and many other traditional cultures that use psychoactive substances within their rituals) the concepts psychopharmacology and psychology do not exist and that the Navajo do not think in terms of these two different fields of science. The symbolism of the rituals is also connected to the broader cultural mythology, through which the healing process is embedded within a wider cultural narrative applicable to all members of this culture. In the West this so-called therapeutic ‘emplotment’ is often aimed at a scientific model of the psyche, or at a personal story that gives direction in the healing process.

By becoming aware of our cultural prejudices through a dialectic with other cultures, we can learn to better understand others and ourselves. Calabrese supports this idea by writing texts that engender empathy and thereby induce a better understanding of the other and therefore of ourselves. By focusing his research on the use of psychoactive substances within a healing ritual that is at the same time spiritual, Calabrese intends to demonstrate that current views on the use of such substances are in need of revision. Instead of focusing on who takes which substance, he pleads in favor of examining the way in which such substances are used within a broader cultural context, and asking the question whether or not this is useful or healing.

In the second part Calabrese further analyzes the symbolism in the rituals of the Native American Church. First he discusses the history of this church and the way in which it has been misunderstood time and again (as a heathen ritual or as an excuse for drug use). He goes on to successively elaborate the view on peyote held by members of the church, the nature of the ceremony and the role the church plays in socialization and the creation of community ties. Lastly, he describes the way in which ceremonies are embedded within Native American mental healthcare.

The members of the church see peyote both as a medicine and as a spirit. Some emphasize the medicinal aspect, others the spiritual aspects, so that no uniform understanding can be identified. Calabrese also notes the personal relation people have with peyote and thereby confirms that personal interpretations remain possible. These interpretations partly fit within the broader (not exclusively Native American Church affiliated) Navajo culture, and partly they are unique to this church.

The ceremony itself is aimed at healing, and the ritual supports this process by means of the various symbols that are central to it. By reflecting on these symbols, communicating with the medicine or the spirit of peyote, and through the transformative power of the experience, the members of the church see their own life in the light of the mythology of death and rebirth within which their healing becomes meaningful. The therapeutic process focuses less on the relation between therapist and patient and more on the personal relationship a person engages in with the medicine within the ritual context.

The members of the church also see the ceremonies as a form of socialization, where family ties and friendships are strengthened. Children are introduced at an early age if they show interest. There is a lot of resistance against this within Western/Christian culture, but Calabrese shows that after several decades of these practices it still hasn’t been proven that such use of peyote by young people within the context of the church has any negative consequences. Peyote is seen as a force that helps strengthen relations and stimulates one to live an ethical life. It also plays a role in the upbringing and development of young Navajo’s. For example, there are special ceremonies to support them in the challenges they face in their regular education, where the group prays for help and guidance.

The Native American Church ceremony has even earned a place in the officially approved treatment methods for young people that have a problematic drug use. This is in sharp contrast with the fact that peyote is officially scheduled as a substance without any medical application. Calabrese has observed in his work at the clinic how the ritual helped support young adults with such problems in their healing process, and simultaneously notes that, because of the official approval of the use of peyote, bureaucracy has shaped the ritual itself. For example, it is required to be aimed at the treatment of addiction in one or more young adults instead of a more general ritual as in the regular church services.

With this book, Calabrese argues for a cultural pluralism within mental healthcare. By connecting patients to rituals and practices from their own cultural backgrounds, a valuable aspect of their healing process is addressed. By participating in peyote ceremonies, young people with substance abuse problems are shown a valuable example of how to use substances in a way that is not destructive, and in many cases even healing. At the same time it reconnects them to their parents and family and restores the ties that have been broken. By acknowledging that there are different ways that can help within a healing process, Calabrese exposes the hegemonic cultural ethnocentrism and the ideological prejudices that often prevent us from thinking clearly about the traditional use of psychoactive substances in different cultures.

In summary this book is an excellent addition to the existing literature on the Native American Church, especially because it tries to acknowledge and circumvent existing cultural prejudices, in order to engender an analysis rooted in mutual respect. This is not only important for the use of a powerful psychedelic substance, but also to bring to light the negative impact of colonialism and to envision a world in which the pain that is still alive among Native Americans can be healed and overcome.

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Harmine for catatonic schizophrenia. A forgotten experiment

Abstract

The purpose of this letter is to present a lesser-known experiment suggesting a positive response of catatonic schizophrenia to Harmine, a monoamine oxidase A inhibitor(MAO-A), a study conducted by Petre Tomescu, in the late 1920’s.

 

Hostiuc, S., Buda, O., & Ion, D. A. (2014). Harmine for catatonic schizophrenia. A forgotten experiment. Schizophrenia research, 1(159), 249-250. http://dx.doi.org/10.1016/j.schres.2014.08.006

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World Ayahuasca Conference 2014

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Het laatste decennium is de belangstelling voor ayahuasca wereldwijd ontzettend toegenomen. Tot haar “recente” ontdekking door de westerse wereld in 1851 bleef ayahuasca, in Zuid-Amerika ook bekend als “la grande medicina”, verborgen in de dichte begroeiing van het Amazonewoud.

Anno 2014 is de wetenschappelijke belangstelling voor ayahuasca niet louter meer een zaak van etnografen en plantkundigen. Meer en meer is het middel de aandacht gaan trekken van allerlei wetenschappers die de effecten, risico’s en therapeutische mogelijkheden ervan willen bestuderen. Deze beweging klinkt als een verre echo van de vroege jaren ’60, toen onderzoek naar psychedelische middelen als LSD op volle toeren draaide, omdat men vermoedde dat ze konden helpen bij een heilzame verkenning van de geest.

Waarom nu? Ayahuasca wordt veel gebruikt als sacrament binnen Santo Daime en União do Vegetal, twee Braziliaanse religieuze bewegingen. Toen vele kerkleden zich in de VS en Europa gingen vestigen begon de kennis over de plant zich in het collectieve bewustzijn te verspreiden – zelfs Sting had het tegenover Rolling Stone Magazine over zijn ervaringen. Vele mensen beschouwen de plant niet als een recreatieve drug, maar als een serieuze en heilige meesterplant. Vanzelfsprekend is samen met de publieke bewustwording ook de belangstelling van wetenschappers toegenomen.

In september aanstaande wil de World Ayahuasca Conference in Ibiza (Spanje) de discussie stimuleren over de rol van de plant in de wetenschap, geneeskunde, therapie en cultuur door vooraanstaande wetenschappers, farmacologen, antropologen, sjamanen en juridische experts samen te brengen. Op het congres zullen ook belangrijke juridische, ethische en duurzaamheidsvraagstukken aan bod komen die verband houden met ayahuasca.

Onder andere sprekers zullen aanwezig zijn: Dennis McKenna, die al meer dan 40 jaar lang medicinale planten bestudeert, Glenn H. Shepard Jr., etnobotanist, medisch antropoloog en filmmaker, en Anya Loizaga-Velder, klinisch psycholoog, die het therapeutisch potentieel van psychedelische planten onderzoekt. De workshops gaan onder andere over het meest recente wetenschappelijk onderzoek naar ayahuasca, het traditionele en religieuze gebruik ervan, de impact van de globalisering op de consumptie van ayahuasca, en over de rol van vrouwen in de wereld van ayahuasca.

Aangezien het gebruik van ayahuasca blijft groeien is een dergelijke multidisciplinaire dialoog noodzakelijk. Vele mensen gebruiken ayahuasca om hun spirituele horizon te verbreden, anderen om depressie en verslaving te bestrijden. Hoewel verder gedetailleerd klinisch onderzoek naar ayahuasca nodig is en er al heel wat op til staat, is het duidelijk dat de populariteit van en de wetenschappelijke belangstelling voor ayahuasca ons veel vertellen over het aanzienlijke potentieel dat deze plant lijkt te hebben voor de genezing van lichaam, geest en ziel.

Klik hier voor meer informatie over de World Ayahuasca Conference.

IJTS Special Topic Section: Ketamine ● Ethnographic Accounts of Ketamine Explorations in Psychedelic Culture

Abstract

Off-label use of ketamine as a mind-altering substance did not begin in the laboratory, but in the psychedelic culture that grew out of the 1960s counterculture movement. Whatever the risks and limitations of such experimentation, without them the remarkable therapeutic effects of the drug might well have gone unnoticed, and unresearched. The following personal accounts—both inspiring and cautionary—offer glimpses into the cultural contexts that found ketamine to be much more than a reliable anesthetic.

Ring, K., Metzner, R., & Wolfson, P. E. (2014). Ethnographic Accounts of Ketamine Explorations in Psychedelic Culture. International Journal of Transpersonal Studies, 33(2).
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IJTS Special Topic Section: Ketamine ● Psychedelic Experiential Pharmacology: Pioneering Clinical Explorations with Salvador Roquet

Abstract

Richard Yensen was a research fellow at the Maryland Psychiatric Research Center from 1972 to 1976. He studied psychedelic psychotherapy with Stanislav Grof, M.D. and other senior staff. During this time he treated patients with substance abuse disorders, cancer, neurosis, and other health professionals seeking a training experience. Dr. Yensen did his Ph.D. dissertation on the use of MDA in psychotherapy with neurotic outpatients and conducted his research at the MPRC. Through many years of experience in governmentsanctioned psychedelic research, he has evolved a non-drug shamanistic psychotherapy called Perceptual Affective Therapy. In the 1990’s Richard was co-holder of IND 3250, an investigational new drug permit issued by the U.S. Food and Drug Administration to study LSD and psychotherapy until 2006. He is currently a licensed psychologist in California and director of the Orenda Institute in Vancouver and Cortes Island, British Columbia, Canada and president of the Salvador Roquet Psychosynthesis Association. He has served on the faculties of Harvard Medical School, Johns Hopkins University and the University of Maryland Medical School in Baltimore.

Wolfson, P. E. (2015). Psychedelic Experiential Pharmacology: Pioneering Clinical Explorations with Salvador Roquet. International Journal of Transpersonal Studies.
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IJTS Special Topic Section: Ketamine ● Making Ketamine Work in the Long Run

Abstract

Treatments such as ketamine psychotherapy face substantial financial and regulatory obstacles to dissemination into widespread use. Newly patented medications are able to generate enough capital to pay for studies required for FDA approval, personnel to apply for coverage on insurance plans, and marketing to establish a successful launch. Ketamine is an older drug with considerable evidence of efficacy for treatment resistant depression, and almost 50 years of data concerning safety as an anesthetic agent. However, it can no longer be patented, so there is no incentive for pharmaceutical companies to help get it into widespread use. In this paper we discuss some of the complex issues surrounding use of ketamine in the outpatient setting and share information and practice pearls that have been gathered through communication with other practitioners and through direct experience with over 1000 treatments involving 120 patients in the last eight years. The safety and appropriateness of intramuscular ketamine treatment in the outpatient psychiatric office is discussed. We hope to help proponents of effective mental health interventions navigate the actual and potential challenges involved in safe application of this treatment option outside of hospital-based programs.

Early, T. S. (2014). Making Ketamine Work in the Long Run. International Journal of Transpersonal Studies, 33(2).
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