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The subjective experience of time during lysergic acid diethylamide (LSD-25) intoxication


A brief review of the literature in relation to time disorder and LSD-25 is given. Twenty nine patients were studied as regards their time experiences under LSD-25. Eight patients reported an altered time experience following the initial administration of the drug. Twelve patients who had not developed a time disturbance in their initial administration, received LSD-25 a second time at increased dosage, 5 of these patients then experienced a time disturbance.

There was a tendency for time disorder to be associated with visual perceptual changes and for it to occur in the non-schizophrenics. Time disorder was considered to be a non-specific response. Recent views on the nature and genesis of time disorders are discussed.

Kenna, J. C., & Sedman, G. (1964). The subjective experience of time during lysergic acid diethylamide (LSD-25) intoxication. Psychopharmacologia5(4), 280-288., 10.1007/BF02341260
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Psychopathology and Psychophysiology of Minimal LSD-25 Dosage


Despite 14 years of investigation, as intensive as accorded any biologically active chemical, a gap remains in the systematic description of human response to lysergic acid diethylamide (LSD-25). The dramatic schizophrenic-like symptoms after doses of 40μg to 100μg have drawn the main interest. The threshold for activity is placed at 20μg by general consensus, while perfunctory administration of smaller doses has left their effect uncertain. Accompanying those pharmacologic demonstrations has been the controversy whether LSD symptoms simulate the psychopathology of schizophrenia1 or can be better explained as a toxic organic psychosis.2 One of these alternatives might be favored by its resemblance to the complete dosage-response relationship of LSD. It is unfortunate for analogical comparison that early stages of toxic psychosis have rarely been described in a psychopathological framework3; on the other hand, there is a firm basis for comparison with various schizophrenic processes. This preliminary note reports

Greiner, T., Burch, N. R., & Edelberg, R. (1958). Psychopathology and psychophysiology of minimal LSD-25 dosage: A preliminary dosage-response spectrum. AMA Archives of Neurology & Psychiatry79(2), 208-210., 10.1001/archneurpsyc.1958.02340020088016
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5‐Hydroxytryptamine. Pharmacological action and destruction in perfused lungs


1. 5-Hydroxytryptamine (HT) caused vasoconstriction and bronchoconstriction in cats’ lungs perfused with blood. These actions were antagonized by dihydroergotamine or lysergic acid diethylamide.

2. The HT-equivalent of the plasma was estimated by extraction with acetone and assay on rat’s uterus in comparison with synthetic HT. This was low immediately after bleeding, but rose rapidly to about 1 mg. per litre.
3. The HT-equivalent of the plasma fell exponentially during perfusion with a halving time of 4-20 min.

4. When the rate of circulation was increased the rate of disappearance of HT rose.

Gaddum, J. H., Hebb, C. O., Silver, A., & Swan, A. A. B. (1953). 5‐Hydroxytryptamine. Pharmacological action and destruction in perfused lungs. Quarterly journal of experimental physiology and cognate medical sciences, 38(4), 255-262.
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