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Salvinorin A reduces neuropathic nociception in the insular cortex of the rat

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Abstract

BACKGROUND:
Neuropathic pain is one of the most important challenges in public health. The search for novel treatments is important for an adequate relief without adverse effects. In this sense salvinorin A (SA), the main diterpene of the medicinal plant Salvia divinorum is an important antinociceptive compound, which acts as a potent agonist of kappa opioid receptor (KOR) and cannabinoid CB1 receptors.
METHODS:
We evaluated nociceptive responses in a neuropathic pain model induced by the sciatic nerve ligature (SNL) in the right hind paw, after the microinjection of SA, Salvinorin B (SB), KOR and CB1 antagonists directly in the insular cortex (IC) in male wistar rats.
RESULTS:
We found a potent antinociceptive effect with the administration of SA. Moreover, this effect was blocked by the administration of a KOR antagonist as well as the administration of a CB1 antagonist.
CONCLUSION:
Salvinorin A has a potent antinociceptive effect when is administered centrally in the IC by the interaction with KOR and CB1 receptors.
SIGNIFICANCE:
We show evidence on the effectiveness of the administration of salvinorin A in the IC in a rodent model of neuropathic pain. These results support the use of novel compounds like SA as a therapeutic alternative for neuropathic pain relief.
Coffeen, U., Canseco‐Alba, A., Simón‐Arceo, K., Almanza, A., Mercado, F., León‐Olea, M., & Pellicer, F. (2017). Salvinorin A reduces neuropathic nociception in the insular cortex of the rat. European Journal of Pain. 10.1002/ejp.1120
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