OPEN Foundation

Matthew Johnson – A Systematic Research Program Examining Psilocybin, Mystical Experience, Personality Change, Adverse Effects and Therapeutic Applications

This talk will describe several lines of research with psilocybin conducted by our laboratory at Johns Hopkins (Baltimore, USA). Completed study results to be presented include: the effects of different psilocybin doses on mystical experience and challenging effects (“bad trips”); the effects of psilocybin in altering personality (increased openness); and the effects of psilocybin on headache. Ongoing studies will also be described, including a study examining psilocybin to treat cancer-related anxiety and depression, a study examining psilocybin to facilitate the adoption of a meditation practice, and a study examining psilocybin in addiction (tobacco smoking) treatment.


Matthew W. Johnson, Ph.D. is Assistant Professor of Psychiatry and Behavioral Sciences at Johns Hopkins University School of Medicine in Baltimore, Maryland, US. He received a Ph.D. in experimental psychology from the University of Vermont, and completed a fellowship in behavioral pharmacology at Johns Hopkins.