OPEN Foundation

Journal Club #26: Esketamine-Assisted Group Schema Therapy for Treatment-Resistant Depression: Study Protocol for a Feasibility RCT

🗣 Lisa-Maria Aldinger, MSc

⏰ Tuesday 4 August, 2026 8PM CEST (7PM BST, 2PM ET, 11AM PST)

📍 Online via Zoom

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Currently, there is a lack of randomized controlled trials (RCTs) evaluating psychedelic-assisted therapy (PAT) using ketamine or esketamine for TRD. In countries like Germany, both substances are predominantly administered as purely medical interventions, often neglecting the therapeutic potential offered by increased neuroplasticity and psychedelic effects. In this Journal Club session, Lisa-Maria will present and discuss her study design and the methodological framework for a feasibility RCT, of a study still yet to be published. Join the conversation and deepen your understanding of the psychedelic field!

Journal Club is an online gathering on Zoom, happening every first Tuesday of each month @8PM CET, where a participant can either present a paper/article of their interest (simply get in touch with us at membership@open-foundation.org if you’d want to give it a go), or sit back and enjoy researchers presenting their own work, followed by a Q&A. For a more thorough description, check this post, and for a more interactive and direct exchange, you’re invited to our Signal group chat once you are a member. 

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ABOUT THE SPEAKER

Lisa-Maria Aldinger is a licensed clinical psychologist and psychotherapist based in Berlin with a decade of clinical experience in integrative behavioral therapy. Her clinical specializations are in trauma therapy, schema-focused therapy, Borderline personality disorder, and working with queer clients—fields she recently focused on while developing an intensive trauma day clinic program at St. Joseph Hospital Berlin. Deeply invested in the future of substance-assisted psychotherapy, she is a ketamine-trained and MAPS-trained therapist dedicated to the clinical implementation and research of PAT. Currently, she bridges clinical expertise and research through her project focusing on the implementation of a psychedelic-assisted therapy model in a routine outpatient Esketamine treatment setting.

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Journal Club #26: Esketamine-Assisted Group Schema Therapy for TRD - Aug 4