OPEN Foundation

Close this search box.

Therapy with Substance: Psycholytic psychotherapy in the twenty first century

Share This Post

Therapy with substance“A unique account and the definitive guide for a future generation of psychedelic psychotherapists. Therapy with Substance is a comprehensive guide for the medical use of psychedelic substances in the therapy of emotional and psychosomatic disorders based on years of work that she had conducted with her clients without official permission. It describes in clear and articulate language everything that is necessary to know for effective and safe use of this treatment modality and for work with non-ordinary states of consciousness in general.”

Stanislav Grof (from the foreword)

In this groundbreaking book, Doctor Friederike Meckel Fischer explores how the skillful use of psychedelic substances in psycholytic psychotherapy can cause dramatic breakthroughs for people who have not responded to traditional methods of psychotherapy. Her extraordinary conclusion is that psycholytic psychotherapy is the only method that reaches the depth of the psyche required to resolve and heal our deepest wounds. Psychedelic drugs were routinely used in clinical research and psychotherapy until the 1960s. Since then they have been illegal except for a short period in the 1990s in Switzerland. During this window of opportunity, Dr Fischer developed her unique method using these substances to assist the progress of those of her patients who were “stuck”.  This book is a description of her use of psychedelic-assisted psychotherapy; the group work, the family constellation work, the body work, the spiritual experiences, how to work with the substances themselves, together with moving accounts of her patients and their stories. This is a unique account and the definitive guide for the new generation of psychedelic psychotherapists.

Dr Meckel is a medical doctor who has trained in individual, group and family psychotherapy and, with Stanislav Grof, in transpersonal psychotherapy.

Therapy with Substance: Psycholytic psychotherapy in the twenty first century, by Friederike Meckel Fischer, Muswell Hill Press, 244 pages.
Read our review of this book
Buy this book at and support the OPEN Foundation.

OPEN Foundation

Join ICPR 2022 Online!

ICPR features world-leading experts from many academic disciplines, including psychiatry, psychology, neuroscience, anthropology, ethnobotany, and philosophy who come together to give a scientific conference for academics, therapists, researchers, clinicians, policymakers, and members of the public. Get your ICPR 2022 livestream ticket today and use the code OPENLIVE30 at checkout for a €30 discount.

Learn More


Subscribe to our new OPEN-Minded newsletter to stay in the loop, hear about our events, and become a part of a community dedicated to advancing psychedelics.

By clicking subscribe, I confirm to receive emails from the OPEN Foundation and agree with its privacy policy.

16 July - NDE's and Psychedelic Experiences: Commonalities & Insights