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Question-based Drug Development for psilocybin

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Abstract

In The Lancet Psychiatry, Robin Carhart-Harris and colleagues conclude that there is preliminary support for the safety and efficacy of psilocybin for treatment-resistant unipolar depression. This finding is important because more effective pharmacological treatments with acceptable side-effects are urgently needed for patients suffering from depression. We support the limitations the authors have pointed out about the study population and trial design. We also recognise the paucity of well-designed trials in psychiatry that are based on the principles of clinical pharmacology.

Dijkstra, F. M., Jacobs, G. E., & Cohen, A. F. (2016). Question-based Drug Development for psilocybin. The Lancet Psychiatry, 3(9), 806-807. http://dx.doi.org/10.1016/S2215-0366(16)30214-0
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