While western civilization slowly opens up to integrating psychedelics in our medical system, the indigenous cultures of South America represent the oldest living heritage of a society that does not carry social stigma towards the ritual usage of these substances. What can we learn from these civilizations and how can Anthropology help us integrate their insights within our cultural framework? How much of this knowledge is lost in translation? How do we even engage a process of mutual consideration and reciprocity that has been lacking until now? Join us in a critical conversation wherein these tension are explored in greater detail.