1. 5-Hydroxytryptamine (HT) caused vasoconstriction and bronchoconstriction in cats’ lungs perfused with blood. These actions were antagonized by dihydroergotamine or lysergic acid diethylamide.
4. When the rate of circulation was increased the rate of disappearance of HT rose.
Gaddum, J. H., Hebb, C. O., Silver, A., & Swan, A. A. B. (1953). 5‐Hydroxytryptamine. Pharmacological action and destruction in perfused lungs. Quarterly journal of experimental physiology and cognate medical sciences, 38(4), 255-262. https://dx.doi.org/10.1113/expphysiol.1953.sp001037
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