OPEN Foundation

Day: 15 July 2017

European Psilocybin Seminar at Tyringham Hall

December 6, 2021 / Articles, Events, Psychiatry, Public Lectures, Publications / By

Tyringham Hall In June 2017, a two-day seminar on psilocybin for European therapists and researchers took place at Tyringham Hall, in the UK. The event was organised by OPEN in collaboration with UK mental health company Compass Pathways.
During a wonderful weekend at Tyringham Hall, near Oxford in the UK, attendees were invited to learn from leading experts in psychedelic-assisted psychotherapy, to discuss necessary competencies and other requirements for clinical applications of psilocybin, and to better understand pathways towards regulatory approval and patient access.
Facilitated by leading experts in the field of psilocybin research and therapy from the US, Switzerland and the UK, the participants discussed competencies for (new) therapists aiming to conduct research into psilocybin for various clinical indications. Attendees could learn from both patients and therapists on the importance of preparing, and supporting people in psilocybin-facilitated treatment at NYU, Imperial College and in Switzerland.
This small meeting consisted of a great mixture of academic researchers, clinicians and therapists from all over Europe: Denmark, Sweden, Norway, Portugal, Switzerland, Germany, Czech Republic, the Netherlands, Israel and the United Kingdom. With serious discussions, plenty of time for everyone to connect and share experiences, in a breath-taking setting, this was an inspiring first meeting of like-minded researchers and clinicians.

Monoamine receptor interaction profiles of 4-thio-substituted phenethylamines (2C-T drugs)

July 15, 2017 / Neuroscience, New substances, Other substances, Papers, Psychopharmacology / By / , , ,

Abstract

BACKGROUND:
4-Thio-substituted phenethylamines (2C-T drugs) are potent psychedelics with poorly defined pharmacological properties. Because of their psychedelic effects, 2C-T drugs are sometimes sold as new psychoactive substances (NPSs). The aim of the present study was to characterize the monoamine receptor and transporter interaction profiles of a series of 2C-T drugs.
METHODS:
We determined the binding affinities of 2C-T drugs at monoamine receptors and transporters in human cells that were transfected with the respective receptors or transporters. We also investigated the functional activation of serotonergic 5-hydroxytryptamine 2A (5-HT2A) and 5-HT2B receptors, activation of human trace amine-associated receptor 1 (TAAR1), and inhibition of monoamine uptake transporters.
RESULTS:
2C-T drugs had high affinity for 5-HT2A and 5-HT2C receptors (1-54 nM and 40-350 nM, respectively). With activation potencies of 1-53 nM and 44-370 nM, the drugs were potent 5-HT2A receptor and 5-HT2B receptor, respectively, partial agonists. An exception to this were the benzylthiophenethylamines, which did not potently activate the 5-HT2B receptor (EC50 > 3000 nM). Furthermore, the compounds bound to serotonergic 5-HT1A and adrenergic receptors. The compounds had high affinity for the rat TAAR1 (5-68 nM) and interacted with the mouse but not human TAAR1. The 2C-T drugs did not potently interact with monoamine transporters (Ki > 4000 nM).
CONCLUSION:
The receptor binding profile of 2C-T drugs predicts psychedelic effects that are mediated by potent 5-HT2 receptor interactions.
Luethi, D., Trachsel, D., Hoener, M. C., & Liechti, M. E. (2017). Monoamine receptor interaction profiles of 4-thio-substituted phenethylamines (2C-T drugs). Neuropharmacology. 10.1016/j.neuropharm.2017.07.012
Link to full text

30 April - Q&A with Rick Strassman

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