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Other substances

DPT as an adjunct in psychotherapy of alcoholics.

January 1, 1973 / Addiction, DMT, Other substances, Papers, Psychiatry, Psychology, Psychopharmacology, Psychotherapy, Publications / By / , , ,

Abstract

The usefulness of dipropyltryptamine (DPT) as an adjunct to psychedelic therapy was explored in a pilot study carried out on 51 alcoholic patients from the Alcoholic Rehabilitation Unit at Spring Grove State Hospital. The evaluation of the results was based on the comparison of pre- and posttreatment results of a battery of psychological tests and of pretreatment and follow-up ratings of an independent team of social workers. The psychological tests involved the Minnesota multiphasic personality inventory (MMPI), Personal orientation inventory (POI), Raven progressive matrices, Psychiatric evaluation profile (PEP), and Benton visual retention test. The social history questionnaire used by the social workers for assessment of the patients’ adjustment consisted of 0-10-point scales measuring residential, occupational and interpersonal adjustment, abstinence, and global adjustment.
Grof, S., Soskin, R. A., Richards, W. A., & Kurland, A. A. (1973). DPT as an adjunct in psychotherapy of alcoholics. International pharmacopsychiatry, 8, 104-115., 10.1159/000467979
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Schizophrenia: A New Approach (Continued)

July 22, 1959 / Chemistry, Other substances, Papers, Psychiatry, Psychology, Psychopharmacology, Psychosis, Publications / By / ,

Abstract

The authors discuss the last five years work of the Saskatchewan group and develop their hypothesis relating adrenaline metabolites to schizophrenia. They also discuss work done in other centres. They indicate some of the difficulties encountered not only in synthesizing adrenochrome and adrenolutin but also in working experimentally with them in human subjects. The successful synthesis of pure stable adrenochrome and adrenolutin has made chemical assay possible. Using their adrenochrome assay, they have found differences between adrenochrome metabolism in normals and schizophrenics. While these require exploration the authors believe that their hypothesis is strong enough to warrant attention or to see whether others can confirm their findings. While adrenochrome and adrenolutin are at present the only metabolites of adrenaline which can be obtained as pure stable compounds and have psychotomimetic properties, there is suggestive evidence that others will be found.

Osmond, H., & Hoffer, A. (1959). Schizophrenia: A new approach (continued). The British Journal of Psychiatry, 105(440), 653-673. https://dx.doi.org/10.1192/bjp.105.440.653
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5‐Hydroxytryptamine. Pharmacological action and destruction in perfused lungs

October 10, 1953 / Other subjects, Other substances, Papers, Psychopharmacology, Publications, Safety / By / , , ,

Abstract

1. 5-Hydroxytryptamine (HT) caused vasoconstriction and bronchoconstriction in cats’ lungs perfused with blood. These actions were antagonized by dihydroergotamine or lysergic acid diethylamide.

2. The HT-equivalent of the plasma was estimated by extraction with acetone and assay on rat’s uterus in comparison with synthetic HT. This was low immediately after bleeding, but rose rapidly to about 1 mg. per litre.
3. The HT-equivalent of the plasma fell exponentially during perfusion with a halving time of 4-20 min.

4. When the rate of circulation was increased the rate of disappearance of HT rose.

Gaddum, J. H., Hebb, C. O., Silver, A., & Swan, A. A. B. (1953). 5‐Hydroxytryptamine. Pharmacological action and destruction in perfused lungs. Quarterly journal of experimental physiology and cognate medical sciences, 38(4), 255-262. https://dx.doi.org/10.1113/expphysiol.1953.sp001037
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30 April - Q&A with Rick Strassman

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